https://scholars.lib.ntu.edu.tw/handle/123456789/370882
標題: | Briacavatolides A-C, NewBriaranes from the Taiwanese Octocoral Briareum excavatum | 作者: | Yeh, T.-T. Wang, S.-K. CHANG-FENG DAI Duh, C.-Y. |
關鍵字: | Anti-HCMV; Briarane-type diterpenoid; Briareum excavatum; Cytotoxicity | 公開日期: | 2012 | 卷: | 10 | 期: | 5 | 起(迄)頁: | 1019-1026 | 來源出版物: | Marine Drugs | 摘要: | In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A-C (1-3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-5 and their cytotoxicity against selected cancer cell lines were evaluated. ? 2012 by the authors. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84862900865&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/370882 |
DOI: | 10.3390/md10051019 | SDG/關鍵字: | antivirus agent; briacavatolide A; briacavatolide B; briacavatolide C; briaexcavatin L; briaexcavatolide U; cytotoxic agent; diterpenoid; mithramycin; unclassified drug; antineoplastic agent; biological product; briaexcavatin; diterpene; animal cell; antineoplastic activity; antiviral activity; article; Briareum excavatum; cancer cell culture; cancer cell destruction; cancer inhibition; carbon nuclear magnetic resonance; colon adenocarcinoma; concentration response; controlled study; cytomegalovirus infection; drug determination; drug isolation; drug structure; human; human cell; IC 50; lung carcinoma; lymphatic leukemia; marine species; nonhuman; proton nuclear magnetic resonance; structure analysis; animal; aquatic species; cell strain HT29; chemistry; Cytomegalovirus; drug effect; isolation and purification; mouse; nuclear magnetic resonance spectroscopy; Taiwan; tumor cell line; Briareum excavatum; Human herpesvirus 5; Animals; Antineoplastic Agents; Aquatic Organisms; Biological Agents; Cell Line, Tumor; Cytomegalovirus; Diterpenes; HT29 Cells; Humans; Magnetic Resonance Spectroscopy; Mice; Taiwan |
顯示於: | 海洋研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。