https://scholars.lib.ntu.edu.tw/handle/123456789/377088
標題: | Hepatoprotection of noni juice against chronic alcohol consumption: Lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation | 作者: | Chang, Y.-Y. Lin, Y.-L. Yang, D.-J. Liu, C.-W. Hsu, C.-L. Tzang, B.-S. YI-CHEN CHEN |
關鍵字: | alcohol metabolism; anti-inflammatory response; antioxidant capacity; lipid homeostasis; noni juice | 公開日期: | 2013 | 卷: | 61 | 期: | 46 | 起(迄)頁: | 11016-11024 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | Chronic alcohol consumption leads to steatohepatitis and cirrhosis. Naturally fermented noni juice (NJ) contains polyphenols, polysaccharides, and some trace minerals. This study explored protective effects of NJ against chronic alcohol consumption. Mice were assigned randomly to one of the following groups: (1) control, control liquid diet and distilled water; (2) alcohol, alcohol liquid diet and distilled water; (3) Alc+NJ-1X, alcohol liquid diet and 5 mL NJ/kg BW; (4) Alc+NJ-2X, alcohol liquid diet and 10 mL NJ/kg BW; (5) Alc+NJ-3X, alcohol and 15 mL NJ/kg BW for 4 weeks. NJ decreased (p < 0.05) serum AST, ALT, and alcohol levels and liver lipids, as well as increased (p < 0.05) daily fecal lipid outputs in alcohol-diet fed mice. NJ supplementation not only down-regulated (p < 0.05) lipogenesis but also up-regulated (p < 0.05) fatty acid β-oxidation in livers of alcohol-diet fed mice. NJ also accelerated alcohol clearance via increased (p < 0.05) hepatic ADH and ALDH activities. NJ increased (p < 0.05) hepatic TEAC and GSH levels but decreased (p < 0.05) TBARS value and TLR2/4, P38, ERK 1/2, NFκB P65, iNOS, COX-2, TNF-α, and IL-1β expressions in alcohol-diet fed mice. NJ promotes hepatoprotection against alcohol-induced injury due to regulations of lipid homeostasis, antioxidant status, alcohol metabolism, and anti-inflammatory responses. ? 2013 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84888367970&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/377088 |
DOI: | 10.1021/jf4038419 | SDG/關鍵字: | Anti-inflammation; Anti-inflammatory response; Antioxidant capacity; Antioxidant status; Chronic alcohols; Lipid homeostasis; noni juice; Protective effects; Antioxidants; Mammals; Metabolism; Nutrition; Physiology; Liquids; alcohol; antioxidant; plant extract; alcohol liver disease; animal; article; beverage; C57BL mouse; chemistry; drinking behavior; drug effect; fruit; human; immunology; lipid metabolism; liver; male; metabolism; Morinda; mouse; Alcohol Drinking; Animals; Antioxidants; Beverages; Ethanol; Fruit; Humans; Lipid Metabolism; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C57BL; Morinda; Plant Extracts |
顯示於: | 動物科學技術學系 |
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