https://scholars.lib.ntu.edu.tw/handle/123456789/378246
標題: | PH-responsive polymeric micelles with core-shell-corona architectures as intracellular anti-cancer drug carriers | 作者: | Bastakoti, B.P. Liao, S.-H. Inoue, M. Yusa, S.-I. Imura, M. Nakashima, K. Wu, K.C.-W. Yamauchi, Y. KEVIN CHIA-WEN WU |
關鍵字: | anti-cancer drug carrier; block copolymer; core-shell-corona micelle; doxorubicin; frozen micelle | 公開日期: | 2013 | 卷: | 14 | 期: | 4 | 來源出版物: | Science and Technology of Advanced Materials | 摘要: | Polymeric micelles with core-shell-corona nanoarchitecture were designed for intracellular therapeutic anti-cancer drug carriers. Poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) asymmetric triblock copolymer underwent self-assembly in aqueous solution to form spherical micelles with hydrophobic PS core, anionic PAA shell and hydrophilic PEG corona. The anti-cancer drug (doxorubicin, DOX) was successfully incorporated into the polymeric micelles. The in vitro release experiment confirmed that the release of DOX from the micelles was inhibited at pH 7.4. In contrast, an accelerated release of DOX was observed at mildly acidic conditions such as pH 4.5. The excellent biocompatibility of our PS-b-PAA-b-PEG-based micelles made the synthesized nano-carrier best suited for the delivery of anti-cancer drugs. ? 2013 National Institute for Materials Science. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84884794462&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/378246 |
DOI: | 10.1088/1468-6996/14/4/044402 | SDG/關鍵字: | Acidic conditions; Anticancer drug; Doxorubicin; Frozen micelles; Nano-architecture; PH-responsive; Polymeric micelle; Spherical micelles; Biocompatibility; Block copolymers; Ethylene glycol; Functional polymers; Polyethylene glycols; Polyethylene oxides; Shells (structures); Styrene; Micelles |
顯示於: | 化學工程學系 |
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