https://scholars.lib.ntu.edu.tw/handle/123456789/390456
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang, S.-J. | en_US |
dc.contributor.author | YUNG-TE HOU | en_US |
dc.contributor.author | LIN-CHI CHEN | en_US |
dc.creator | Wang, S.-J.;Hou, Y.-T.;Chen, L.-C. | - |
dc.date.accessioned | 2018-09-10T15:18:19Z | - |
dc.date.available | 2018-09-10T15:18:19Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84938917594&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/390456 | - |
dc.description.abstract | A novel selective decoy oligodeoxynucleotide (dODN)-doxorubicin (DOX) complex is reported for cancer theranostics. It eliminates the use of a ligand or carrier for targeted delivery and disassembles into therapeutic dODN and DOX upon encountering over-activated STAT3 in cancer cells. Hence, in situ STAT3 probing and synergistic anti-cancer effect are attained at the same time. ? 2015 Royal Society of Chemistry. | - |
dc.language | en | en |
dc.relation.ispartof | Chemical Communications | - |
dc.source | AH | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aptamer; bovine serum albumin; doxorubicin; lipofectamine; oligodeoxynucleotide; quantum dot; STAT3 protein; streptavidin; antineoplastic agent; doxorubicin; drug carrier; fluorescent dye; lipid; oligodeoxyribonucleotide; STAT3 protein; STAT3 protein, human; antineoplastic activity; apoptosis; Article; binding affinity; binding competition; cancer cell; cell death; circular dichroism; competitive binding assay; drug potentiation; drug release; fluorescence microscopy; liposomal delivery; malignant neoplastic disease; MCF 7 cell line; protein binding; ultraviolet spectroscopy; antagonists and inhibitors; chemistry; HepG2 cell line; human; theranostic nanomedicine; Antineoplastic Agents; Doxorubicin; Drug Carriers; Fluorescent Dyes; Hep G2 Cells; Humans; Lipids; MCF-7 Cells; Oligodeoxyribonucleotides; STAT3 Transcription Factor; Theranostic Nanomedicine | - |
dc.title | A selective decoy-doxorubicin complex for targeted co-delivery, STAT3 probing and synergistic anti-cancer effect | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1039/c5cc04435a | - |
dc.relation.pages | 13309-13312 | - |
dc.relation.journalvolume | 51 | - |
dc.relation.journalissue | 68 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Biomechatronics Engineering | - |
crisitem.author.dept | Biomechatronics Engineering | - |
crisitem.author.dept | Office of Academic Affairs | - |
crisitem.author.dept | Others: Center for General Education | - |
crisitem.author.orcid | 0000-0002-4978-9829 | - |
crisitem.author.orcid | 0000-0001-5947-2019 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | National Taiwan University | - |
顯示於: | 生物機電工程學系 |
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