https://scholars.lib.ntu.edu.tw/handle/123456789/393149
標題: | High agatston calcium score of intracranial carotid artery: A significant risk factor for cognitive impairment | 作者: | HSIAO-WEN CHUNG | 公開日期: | 2015 | 卷: | 94 | 期: | 39 | 來源出版物: | Medicine | 摘要: | The effect of intracranial internal carotid artery (ICA) calcification on cognitive impairment is uncertain. Our objective was to investigate whether intracranial ICA calcification is a significant cognitive predictor for cognitive impairment. Global cognition and degrees of intracranial ICA calcification of 579 subjects were assessed with Mini-Mental State Examination (MMSE) and Agatston calcium scoring method, respectively. Other risk factors for cognitive impairment, including age, education level, hypertension, diabetes mellitus, smoking, hyperlipidemia, and body mass index, were documented and analyzed for their associations with cognitive function. In univariate analyses, older age, lower education level, hypertension, diabetes mellitus, and higher intracranial ICA Agatston scores were significantly associated with cognitive impairment. In ordinal logistic regression, only age and total intracranial ICA Agatston score were significant risk factors for cognitive impairment. After adjustment for the other documented risk factors, subjects were 7% (95% CI: 5-10; P<0.001) and 6%(95% CI: 0-13; P=0.04) more likely to have lower cognitive category with every year increment of age and every 100-point increment of the total intracranial ICA Agatston score respectively. These results suggest an important role of the intracranial ICA calcification on cognitive impairment. Copyright ? 2015 Wolters Kluwer Health, Inc. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84943174557&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/393149 |
DOI: | 10.1097/MD.0000000000001546 | SDG/關鍵字: | adult; Agatston score; aged; artery calcification; Article; body mass; carotid artery disease; cognition; cognitive defect; computer assisted tomography; controlled study; diabetes mellitus; educational status; female; human; hyperlipidemia; hypertension; intracranial internal carotid artery calcification; major clinical study; male; mild cognitive impairment; Mini Mental State Examination; priority journal; smoking; calcinosis; carotid artery disease; Cognition Disorders; complication; internal carotid artery; middle aged; prospective study; risk factor; severity of illness index; very elderly; Adult; Aged; Aged, 80 and over; Calcinosis; Carotid Artery Diseases; Carotid Artery, Internal; Cognition Disorders; Female; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Severity of Illness Index |
顯示於: | 生醫電子與資訊學研究所 |
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