https://scholars.lib.ntu.edu.tw/handle/123456789/396747
標題: | Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy | 作者: | Cheng, C.-H. Wu, H.-Y. Wu, C.-F. TONG-RONG JAN |
關鍵字: | Crassostrea gigas; food allergy; oyster; polysaccharides; T helper | 公開日期: | 2016 | 卷: | 24 | 期: | 1 | 起(迄)頁: | 121-128 | 來源出版物: | Journal of Food and Drug Analysis | 摘要: | Oyster-derived polysaccharides (OPS) have been shown to modulate the T helper (Th)1/Th2 immunobalance toward the Th1-dominant direction in antigen-primed splenocytes. In the present study, we hypothesized that OPS might attenuate intestinal inflammation associated with food allergy, a Th2-dominant immune disorder. BALB/c mice were sensitized twice with ovalbumin (OVA) absorbed to alum and then repeatedly challenged with intragastric OVA to induce intestinal allergic responses. The mice were administered by gavage with OPS and/or vehicle (distilled water) once/d during the two sensitization phases, and once every other day during the challenge phase. Administration with OPS attenuated OVA challenge-elicited diarrhea, and the infiltration of mast cells in the intestine. OPS demonstrated a protective effect on the reduced ratio of villus length over crypt depth of the intestine in allergic mice. Furthermore, OPS administration markedly attenuated the intestinal expression of the Th2 signature cytokine interleukin-4 (IL-4). Collectively, these results demonstrated the in vivo antiallergic activity of OPS, which is associated with the suppression of allergen-induced intestinal Th2 responses and mast cell activation. ? 2015, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84957431405&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/396747 |
DOI: | 10.1016/j.jfda.2015.08.006 | SDG/關鍵字: | antiallergic agent; interleukin 4; ovalbumin; oyster derived polysaccharide; unclassified drug; animal experiment; animal model; animal tissue; Article; autopsy; cell activation; diarrhea; duodenum; enteritis; food allergy; in vivo study; intestinal tissue; male; mast cell; mast cell degranulation; mouse; nonhuman; Th2 cell |
顯示於: | 獸醫學系 |
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