https://scholars.lib.ntu.edu.tw/handle/123456789/402805
標題: | A digital assessment system for evaluating kinetic tremor in essential tremor and Parkinson's disease | 作者: | KAI-HSIANG CHEN Lin, Po-Chieh; Yang, Bing-Shiang; Chen, Yu-Jung |
關鍵字: | Clinical assessment; Essential tremor; Parkinson's disease; Spiral drawing | 公開日期: | 2018 | 卷: | 18 | 期: | 1 | 來源出版物: | BMC Neurology | 摘要: | Background: Spiral drawing on papers is a common tremor evaluation tool for diagnosing patients with essential tremor (ET) or Parkinson's disease (PD). No standard drawing methods and parameters that use graphic tablets are yet available for objective evaluation. Methods: This study established a tremor assessment system for tremor severity by using graphic tablets. Twelve patients with ET and twelve patients with PD were tested to establish system algorithms, and six additional patients were tested with the developed system to evaluate its performance. The patients also performed spiral drawing with three guiding paradigms on a graphic tablet: traced along a given spiral (S1), performed freehand drawing (S2), and traced along a guiding point (S3). Three parameters were calculated to quantify tremor severity: the means of radial difference per radian (dr/dθ), the means of radial difference per second (dr/dt), and the area under curve (AUC) of the frequency spectrum of the velocity. Each patient's drawing was also evaluated using a visual rating scale (VRS) by experienced physicians. The interrater reliability was examined to identify the most consistent test paradigm. Results: The parameter dr/dθ and AUC correlated well with the VRS (R > 0.8) in S1, S2 and S3 tests. The S1 test presented the best interrater reliability (Weighted Kappa coefficient, k = 0.80) among three tests. The Weighted Kappa coefficients are 0.67 and 0.71 in S2 and S3 tests, respectively. Conclusions: We developed three different guiding paradigms for spiral drawing on a digital graphic tablet for clinical tests. Three parameters were calculated to represent the tremor severity in spiral drawing and used to quantify temporal and spatial characteristics of tremor, and provided good correlation with current clinical assessments. The test "traced along a given spiral" is recommended due to its good interrater reliability. ? 2018 The Author(s). |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-85043467425&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/402805 |
DOI: | 10.1186/s12883-018-1027-2 | SDG/關鍵字: | aged; area under the curve; Article; clinical article; clinical assessment tool; correlation coefficient; disease severity assessment; drawing; essential tremor; human; interrater reliability; Parkinson disease; rating scale; spiral drawing test; task performance; velocity; visual rating scale; complication; essential tremor; female; male; middle aged; motor performance; neurologic examination; Parkinson disease; personal digital assistant; procedures; reproducibility; tremor; Aged; Computers, Handheld; Essential Tremor; Female; Humans; Male; Middle Aged; Motor Skills; Neurologic Examination; Parkinson Disease; Reproducibility of Results; Tremor |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。