https://scholars.lib.ntu.edu.tw/handle/123456789/410323
標題: | Modification and crosslinking of gelatin-based biomaterials as tissue adhesives | 作者: | Liu Y. Cheong NG S. Yu J. Tsai W.-B. |
關鍵字: | Dopamine;Gelatin;Ion-crosslink;Phloretic acid;Photo-crosslink;Tissue adhesive | 公開日期: | 2019 | 卷: | 174 | 起(迄)頁: | 316-323 | 來源出版物: | Colloids and Surfaces B: Biointerfaces | 摘要: | Tissue adhesives have been developed to overcome the difficulties of conventional wound closure techniques (e.g. sutures and staples), such as the potential for collateral damage and difficulty of stopping body fluid and gas. At the same time, it provides advantages such as simpler implementation, less painful, and does not require removal. However, representative adhesives such as cyanoacrylates and fibrin glues are plagued by cytotoxicity and low adhesion. In this study, we choose instead gelatin as the backbone of adhesive, due to its biocompatibility, biodegradability, and low cost. Firstly, catechol-modified gelatin and phenol-modified gelatin were synthesized via an EDC/NHS chemistry. Then, gelatin-based adhesives were prepared via ruthenium-based photochemistry, including photo-crosslinked gelatin (PG), phenol-modified gelatin (PPG), and catechol-modified gelatin (PCG). We also compared the photo-crosslinked adhesives to the recently reported ion-crosslinked catechol-modified gelatin. Our results indicate that gelatin-based adhesives demonstrate lower swelling index, great degradability, and low cytotoxicity. This shows that gelatin-based adhesives demonstrate great potential for wound closure and healing. ? 2018 Elsevier B.V. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/410323 | ISSN: | 09277765 | DOI: | 10.1016/j.colsurfb.2018.10.077 |
顯示於: | 化學工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。