https://scholars.lib.ntu.edu.tw/handle/123456789/413601
Title: | Corn oil enhances £^-glutamyl transpeptidase-positive foci development in the presence of phenobarbital during hepatocarcinogenesis in rats | Authors: | Chen H.-W. Ko J.-J. Lii C.-K. Ou C.-C. Sheen L.-Y. |
Issue Date: | 1997 | Journal Volume: | 28 | Journal Issue: | 3 | Start page/Pages: | 252-257 | Source: | Nutrition and Cancer | Abstract: | We investigated the effects of type of dietary fat and phenobarbital on £^-glutamyl transpeptidase-positive foci development. Four groups of six female Sprague-Dawley rats were initiated with diethylnitrosamine (15 mg/kg) at 24 hours of age. After weaning, they were fed nutritionally complete semipurified diets containing 15% corn oil or 5% corn oil + 10% fish oil and supplemented with 5,000 ppm vitamin E with or without phenobarbital (500 ppm) for three months. Dietary fish oil significantly increased hepatic phospholipid eicosapentaenoate and docosahexaenoate concentrations and decreased arachidonate concentration compared with 15% corn oil (p < 0.05). Corn oil (15%) significantly increased hepatic prostaglandin F2£\ concentration compared with 10% fish oil (p < 0.05). Phenobarbital significantly stimulated glutathione S-transferase activity in both dietary fat groups (p < 0.05). In the absence of phenobarbital, type of dietary fat showed no effect on hepatic £^-glutamyl transpeptidase-positive loci development. However, in the presence of phenobarbital, 15% corn oil significantly enhanced £^-glutamyl transpeptidase-positive foci development compared with 10% fish oil (p < 0.05). Phenobarbital showed a strong tumor- promoting action in both dietary groups. In conclusion, there was an interaction between type of dietary fat and phenobarbital on £^-glutamyl transpeptidase-positive foci development during hepatocar- cinogenesis in rats. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/413601 | ISSN: | 1635581 | DOI: | 10.1080/01635589709514584 |
Appears in Collections: | 食品科技研究所 |
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