https://scholars.lib.ntu.edu.tw/handle/123456789/426021
Title: | Ameliorative effects of pepsin-digested chicken liver hydrolysates on development of alcoholic fatty livers in mice | Authors: | Yi-Ling Lin Szu-Yun Tai Jr-Wei Chen CHUNG-HSI CHOU Shih-Guei Fu YI-CHEN CHEN |
Issue Date: | 2017 | Journal Volume: | 8 | Start page/Pages: | 1763-1774 | Source: | Food & Function | Abstract: | With developments in economics and increasing work loads, alcohol abuse becomes more and more severe, leading to occurrences of alcoholic liver disease (ALD). Pepsin-digested chicken liver hydrolysates (CLHs) contain high amounts of glutamic acid, leucine, lysine, and alanine while the contents of taurine, anserine, and carnosine are also elevated after pepsin hydrolyzation. The objectives of this study were to evaluate the protective effects of CLHs against chronic alcohol consumption. The results indicated that the enlarged (p < 0.05) sizes of liver and spleen, and serum AST, ALT, and ALKP levels of mice fed with an alcoholic diet were ameliorated by supplementing with CLHs. Moreover, increased hepatic immunocyte infiltration shown on the H&E staining and higher (p < 0.05) hepatic triglyceride contents, TBARS values, and proinflammatory cytokine levels in alcoholic diet fed mice were also reduced (p < 0.05) by supplementing with CLHs. Those benefits were attributed to up-regulated fatty acid β-oxidation and down-regulated fatty acid synthesis, as well as increased (p < 0.05) SOD, CAT, and GPx activities, TEAC levels, and elevated alcohol metabolic enzymatic activities (ALDH). ? 2017 The Royal Society of Chemistry. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/426021 | DOI: | 10.1039/c7fo00123a | SDG/Keyword: | Amino acids; Animals; Biological materials; Biomarkers; Mammals; Beta oxidation; Chicken liver; Chronic alcohols; Enzymatic activities; Fatty acid synthesis; GPx activities; Proinflammatory cytokines; Protective effects; Fatty acids; alanine aminotransferase; pepsin A; protein hydrolysate; triacylglycerol; alcoholic fatty liver; animal; blood; C57BL mouse; chemistry; chicken; diet therapy; human; liver; male; metabolism; mouse; Alanine Transaminase; Animals; Chickens; Fatty Liver, Alcoholic; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Pepsin A; Protein Hydrolysates; Triglycerides |
Appears in Collections: | 動物科學技術學系 |
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