https://scholars.lib.ntu.edu.tw/handle/123456789/434746
Title: | Defective adrenergic responses in patients with arsenic-induced peripheral vascular disease | Authors: | Lee C.-H. Chang H.-R. JAU-SHIUH CHEN Chen G.-S. Yu H.-S. |
Issue Date: | 2007 | Journal Volume: | 58 | Journal Issue: | 2 | Start page/Pages: | 161-168 | Source: | Angiology | Abstract: | Blackfoot disease is an endemic arsenic-induced peripheral vascular disease in southern Taiwan. The main pathologic feature is atherosclerosis, which may relate to imbalances of the adrenergic system. The purpose of this study is to investigate the peripheral adrenergic responses of patients with blackfoot disease. Eight patients with blackfoot disease and four age-matched healthy controls were enrolled in this study. Baseline cutaneous perfusion was measured with a laser Doppler flowmeter. The response of alpha-adrenoceptors in the cutaneous microcirculation was assessed with laser Doppler flowmetry with iontophoresis of phenylephrine into the nailfold. In vitro binding with 125I-cyanopindolol determined beta-adrenoceptor density in lymphocytes. The cyclic adenosine monophosphate (cAMP) level at baseline and after isoproterenol stimulation reflects lymphocyte beta-adrenergic responsiveness. Results revealed persistently decreased skin perfusion in patients with blackfoot disease. In contrast, there was a transient decrease in skin perfusion in healthy controls after iontophoresis of phenylephrine. Both beta-2 receptor density and isoproterenol-stimulated cAMP levels in lymphocytes decreased. Increased peripheral alpha-adrenergic response and decreased beta-2-adrenergic response are related to increased vascular tone and result in atherosclerosis. Our findings of accentuated alpha-adrenergic response in microcirculation and decreased lymphocyte beta-2-adrenoceptor response play an important role in the pathogenesis of atherosclerosis in blackfoot disease. ?2007 Sage Publications. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247601736&doi=10.1177%2f0003319707300351&partnerID=40&md5=2faa605715915c80aad3c8554db2d4a3 https://scholars.lib.ntu.edu.tw/handle/123456789/434746 |
ISSN: | 0003-3197 | DOI: | 10.1177/0003319707300351 | SDG/Keyword: | alpha adrenergic receptor; arsenic; beta 2 adrenergic receptor; cyanopindolol i 125; cyclic AMP; isoprenaline; phenylephrine; adrenergic activity; adrenergic system; adult; age distribution; aged; article; atherosclerosis; blackfoot disease; blood vessel tone; cerebrovascular accident; clinical article; controlled study; coronary artery disease; Doppler flowmeter; erythema; female; gangrene; human; in vitro study; intermittent claudication; iontophoresis; lymphocyte; male; microcirculation; microvasculature; nail; peripheral vascular disease; Raynaud phenomenon; skin blood flow; ulcer; Adrenergic beta-Agonists; Aged; Aged, 80 and over; Arsenic Poisoning; Blood Flow Velocity; Case-Control Studies; Cyclic AMP; Female; Humans; Iontophoresis; Isoproterenol; Laser-Doppler Flowmetry; Leg; Lymphocytes; Male; Microcirculation; Middle Aged; Peripheral Vascular Diseases; Receptors, Adrenergic; Risk Factors; Taiwan; Water Pollutants, Chemical; Water Supply |
Appears in Collections: | 醫學系 |
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