https://scholars.lib.ntu.edu.tw/handle/123456789/434980
標題: | Staphylococcus colonization in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics | 作者: | Hung S.-H. YU-TSAN LIN CHIA-YU CHU CHIEN-CHANG LEE Liang T.-C. YAO-HSU YANG LI-CHIEH WANG BOR-LUEN CHIANG |
公開日期: | 2007 | 出版社: | American College of Allergy, Asthma and Immunology | 卷: | 98 | 期: | 1 | 起(迄)頁: | 51-56 | 來源出版物: | Annals of Allergy, Asthma and Immunology | 摘要: | Background: The skin of patients with atopic dermatitis (AD) exhibits a striking susceptibility to colonization and infection by Staphylococcus aureus. Treatment with topical anti-inflammatory drugs alone can reduce S aureus colonization. Objectives: To compare the clinical severity of AD and the S aureus colonization rate between AD patients treated with topical glucocorticoids and those treated with tacrolimus and to evaluate the effects of complementary topical antistaphylococcal antibiotic therapy and the development of fusidic acid-resistant S aureus. Methods: Sixty AD patients were enrolled in a prospective, parallel, randomized study of an 8-week treatment with topical 0.05% fluticasone propionate or 0.03% tacrolimus, with or without complementary fusidic acid. Disease severity scoring of AD based on SCORing of Atopic Dermatitis (SCORAD), colonization rate and density of S aureus on the skin, and antibiotic susceptibility of S aureus isolates were evaluated. Results: The reduction in SCORAD scores correlated with the reduction of S aureus numbers. Treatment with topical tacrolimus resulted in a comparable reduction in SCORAD scores to fluticasone but a slower eradication of S aureus. Complementary fusidic acid had no additional benefit compared with fluticasone or tacrolimus alone. Two patients developed fusidic acid-resistant S aureus after 8 weeks of fusidic acid treatment. Conclusion: Tacrolimus is an appropriate alternative treatment for chronic AD. Topical anti-inflammatory therapy alone to improve the allergic skin inflammation of AD can reduce S aureus colonization of the skin. Topical antibiotics should be reserved for short-term use in obvious secondary bacterial infection. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846252330&doi=10.1016%2fS1081-1206%2810%2960859-9&partnerID=40&md5=1f64749c8d2d4d977bfc36c20364d65a https://scholars.lib.ntu.edu.tw/handle/123456789/434980 |
ISSN: | 1081-1206 | DOI: | 10.1016/S1081-1206(10)60859-9 | SDG/關鍵字: | antibiotic agent; antiinflammatory agent; cetirizine; fluticasone propionate; fusidate sodium; fusidic acid; glucocorticoid; tacrolimus; adolescent; adult; antibiotic sensitivity; article; atopic dermatitis; bacterial colonization; bacterium isolate; burning sensation; child; clinical trial; controlled clinical trial; controlled study; disease severity; drug withdrawal; eradication therapy; female; human; infant; infection sensitivity; major clinical study; male; multiple cycle treatment; nonhuman; patient compliance; priority journal; prospective study; pruritus; randomized controlled trial; skin allergy; sleep disorder; Staphylococcus aureus; treatment outcome |
顯示於: | 醫學系 |
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