https://scholars.lib.ntu.edu.tw/handle/123456789/439125
標題: | Association of HLA-DR14-DR52 with low responsiveness to hepatitis B vaccine in Chinese residents in Taiwan | 作者: | HONG-YUAN HSU MEI-HWEI CHANG HONG-NERNG HO Hsieh R.-P. Lee S.-D. Chen D.-S. Lee C.-Y. Hsieh K.-H. |
公開日期: | 1993 | 卷: | 11 | 期: | 14 | 起(迄)頁: | 1437-1440 | 來源出版物: | Vaccine | 摘要: | To determine the HLA-linked immune response gene that controls low responsiveness to hepatitis B surface antigen (HBsAg), HLA typing was performed in 33 initial non-responders (male:female = 23:10, age 1.5-46 years) who had poor antibody response (anti-HBs < 10 mIU ml-1) after four doses of plasma-derived hepatitis B vaccine. Of 33 initial non-responders, 26 received two additional doses of either the same vaccine (n = 18) or recombinant hepatitis B vaccine (n = 8) and returned for anti-HBs measurement. At 1 month after the sixth dose, anti-HBs was still <10 mIU ml-1 in 20 cases and 10-20 mIU ml-1 in three cases. Analysis of HLA antigen frequencies in these 23 ultimate low responders revealed that nine (39%) were positive for DR14, a statistically significant association of low responsiveness to hepatitis B vaccine with HLA-DR14. In addition, 26% of the ultimate low-responders were positive for DQ3, a frequency significantly lower than the expected rate in the general population. Among the nine ultimate low-responders with DR14, seven were heterozygous for this allele, while the other two cases had a single isolated DR14; and all nine were in association with DR52. These results suggest that a DR14-DR52 association, probably dominantly expressed, may be involved in the low immune responsiveness to hepatitis B vaccine of the Chinese population in Taiwan. ? 1993. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027424902&doi=10.1016%2f0264-410X%2893%2990173-U&partnerID=40&md5=ec2965aa57514769b4af3070da30fef7 https://scholars.lib.ntu.edu.tw/handle/123456789/439125 |
ISSN: | 0264-410X | DOI: | 10.1016/0264-410X(93)90173-U | SDG/關鍵字: | hepatitis b vaccine; HLA DR antigen; article; controlled study; ethnic group; hepatitis b; hepatitis b virus; HLA typing; human; human cell; immune response; major clinical study; priority journal; taiwan; vaccination; Adolescent; Adult; Antibody Formation; Child; Child, Preschool; China; Female; Genetic Markers; Hepatitis B Surface Antigens; Hepatitis B Vaccines; HLA Antigens; HLA-DR Antigens; Human; Infant; Infant, Newborn; Male; Middle Age; Support, Non-U.S. Gov't; Taiwan; Vaccination |
顯示於: | 醫學教育暨生醫倫理學科所 |
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