|Title:||Association of HLA-DR14-DR52 with low responsiveness to hepatitis B vaccine in Chinese residents in Taiwan||Authors:||HONG-YUAN HSU
|Issue Date:||1993||Journal Volume:||11||Journal Issue:||14||Start page/Pages:||1437-1440||Source:||Vaccine||Abstract:||
To determine the HLA-linked immune response gene that controls low responsiveness to hepatitis B surface antigen (HBsAg), HLA typing was performed in 33 initial non-responders (male:female = 23:10, age 1.5-46 years) who had poor antibody response (anti-HBs < 10 mIU ml-1) after four doses of plasma-derived hepatitis B vaccine. Of 33 initial non-responders, 26 received two additional doses of either the same vaccine (n = 18) or recombinant hepatitis B vaccine (n = 8) and returned for anti-HBs measurement. At 1 month after the sixth dose, anti-HBs was still <10 mIU ml-1 in 20 cases and 10-20 mIU ml-1 in three cases. Analysis of HLA antigen frequencies in these 23 ultimate low responders revealed that nine (39%) were positive for DR14, a statistically significant association of low responsiveness to hepatitis B vaccine with HLA-DR14. In addition, 26% of the ultimate low-responders were positive for DQ3, a frequency significantly lower than the expected rate in the general population. Among the nine ultimate low-responders with DR14, seven were heterozygous for this allele, while the other two cases had a single isolated DR14; and all nine were in association with DR52. These results suggest that a DR14-DR52 association, probably dominantly expressed, may be involved in the low immune responsiveness to hepatitis B vaccine of the Chinese population in Taiwan. ? 1993.
|ISSN:||0264-410X||DOI:||10.1016/0264-410X(93)90173-U||SDG/Keyword:||hepatitis b vaccine; HLA DR antigen; article; controlled study; ethnic group; hepatitis b; hepatitis b virus; HLA typing; human; human cell; immune response; major clinical study; priority journal; taiwan; vaccination; Adolescent; Adult; Antibody Formation; Child; Child, Preschool; China; Female; Genetic Markers; Hepatitis B Surface Antigens; Hepatitis B Vaccines; HLA Antigens; HLA-DR Antigens; Human; Infant; Infant, Newborn; Male; Middle Age; Support, Non-U.S. Gov't; Taiwan; Vaccination
|Appears in Collections:||醫學教育暨生醫倫理學科所|
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