https://scholars.lib.ntu.edu.tw/handle/123456789/452629
Title: | Dietary flavonoids luteolin and quercetin suppressed cancer stem cell properties and metastatic potential of isolated prostate cancer cells | Authors: | Tsai, Pei-Hsun Cheng, Chia-Hsiung Lin, Chun-Yu Huang, Ying-Tang Lee, Lung-Ta Kandaswami, Chithan C. Lin, Yo-Chuen Lee, Kevin Po-Hao Hung, Chin-Chun Hwang, Jiuan-Jiuan Ke, Ferng-Chun GEEN-DONG CHANG Lee, Ming-Ting |
Keywords: | Cancer stem cell; Luteolin; Metastasis; Prostate cancer; Quercetin; Vasculogenic mimicry | Issue Date: | 2016 | Journal Volume: | 36 | Journal Issue: | 12 | Start page/Pages: | 6367 - 6380 | Source: | Anticancer Research | Abstract: | A highly invasive Du145-III subline was isolated by three successive passages of the parental Du145 prostate tumor cell line (Du145-P) through a Boyden chamber with matrigel-coated membrane support. Du145-III cells showed great invasion potential based on their increased ability to spread/migrate and enhanced expression/secretion of the matrix metalloproteinase 9 (MMP9). Du145-III cells exerted vasculogenic mimicry (VM) properties, reminiscent of endothelial cell characteristics and expressed elevated levels of cancer stem cell (CSC) markers, including Nanog, Sox2, CD44 and ABCG2 and ability to self-renew. Of prominence, MMP9 was required for the induction of VM and for increased stemness in Du145-III cells. Using Du145-III as a model, the effects of dietary flavonoids, luteolin and quercetin, were evaluated on stemness and invasion capacity of Du145-III cells in relation to JNK signaling pathway activation. These flavonoids depressed the malignancy of highly invasive Du145-III cells, VM, anchorage-independent spheroid formation and expression of certain CSC markers. Since luteolin and quercetin were able to target CSC cells and prevent cancer cell invasiveness, may serve as potential anti-angiogenesis and anti-metastasis agents. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/452629 https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85002487118&doi=10.21873%2fanticanres.11234&partnerID=40&md5=cb56640f19df7df01db46a091da99f6d |
ISSN: | 02507005 | DOI: | 10.21873/anticanres.11234 | SDG/Keyword: | breast cancer resistance protein; gelatinase B; Hermes antigen; luteolin; quercetin; transcription factor NANOG; transcription factor Sox2; luteolin; quercetin; Article; cancer stem cell; controlled study; drug effect; enzyme release; metastasis potential; priority journal; prostate cancer; prostate cancer cell line; protein expression; stem cell self-renewal; cancer stem cell; chemistry; diet; drug effects; human; male; pathology; prostate tumor; Diet; Humans; Luteolin; Male; Neoplastic Stem Cells; Prostatic Neoplasms; Quercetin |
Appears in Collections: | 生化科學研究所 |
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