https://scholars.lib.ntu.edu.tw/handle/123456789/454597
標題: | Sialyl Glycan Expression on T Cell Subsets in Asthma: a correlation with disease severity and blood parameters | 作者: | Yeh, Yu-Liang Wu, Wen-Chia Kannagi, Reiji BOR-LUEN CHIANG Liu, Fu-Tong YUNG-LING LEE |
公開日期: | 20-六月-2019 | 出版社: | NATURE PUBLISHING GROUP | 卷: | 9 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | Memory T helper (Th) and regulatory T (Treg) cells play key roles in asthma. Certain sialyl carbohydrate determinants for selectins profoundly affect the migratory properties of memory Th cells, and the suppressive function of Treg cells. Previous studies have shown that the proportion of CCR4+ memory Th cells expressing sialyl 6-sulfo Lewis X (LeX) is elevated in asthma patients. We aim to investigate the roles of different sialyl glycans on T cell subsets in asthma. Using flow cytometry, we assessed the expression of three sialyl glycans, sialyl 6-sulfo LeX, cyclic sialyl 6-sulfo LeX, and sialyl LeX on memory Th and Treg cells, in the peripheral blood of asthmatic children. We also assessed the relationships between glycan-expressing cell percentages and asthma clinical parameters. Compared with controls, asthmatic children showed higher proportions of memory Th cells expressing sialyl LeX and sialyl 6-sulfo LeX. The proportions of memory Th cells with sialyl 6-sulfo LeX and cyclic sialyl 6-sulfo LeX expression in asthmatic children correlated with absolute eosinophil count and IgE level, respectively. Children with moderate-to-severe asthma had lower numbers of sialyl LeX positive Treg cells. Our study suggests that sialyl glycans on T cells may play important roles in the pathogenesis of asthma. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/454597 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-019-45040-2 | SDG/關鍵字: | n acetylneuraminic acid; polysaccharide; asthma; blood; case control study; child; human; male; metabolism; preschool child; severity of illness index; T lymphocyte; T lymphocyte subpopulation; Asthma; Case-Control Studies; Child; Child, Preschool; Humans; Male; N-Acetylneuraminic Acid; Polysaccharides; Severity of Illness Index; T-Lymphocyte Subsets; T-Lymphocytes |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。