https://scholars.lib.ntu.edu.tw/handle/123456789/456360
標題: | The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review | 作者: | Lazarides A.L. Eward W.C. Speicher P.J. CHUN-HAN HOU Nussbaum D.P. Green C. Blazer D.G. III Kirsch D.G. Brigman B.E. |
公開日期: | 2015 | 出版社: | Hindawi Publishing Corporation | 卷: | 2015 | 來源出版物: | Sarcoma | 摘要: | Objective. This study investigated patterns of utilization of radiation therapy (RT) and correlated this with overall survival by assessing patients with well-differentiated soft tissue sarcoma of the extremity (STS-E) in the National Cancer Database (NCDB). Methods. All patients diagnosed with well-differentiated STS-E between 1998 and 2006 were identified in the NCDB. Patients were stratified by use of surgery alone versus use of adjuvant RT after surgery and analyzed using multivariate analysis, Kaplan-Meier analysis, and propensity matching. Results. 2113 patients with well-differentiated STS-E were identified in the NCDB for inclusion with a mean follow-up time of 74 months. 69% of patients were treated with surgery alone, while 26% were treated with surgery followed by adjuvant RT. Patients undergoing amputation were less likely to receive adjuvant RT. There was no difference in overall survival between patients with well-differentiated STS treated with surgery alone and those patients who received adjuvant RT. Conclusions. In the United States, adjuvant RT is being utilized in a quarter of patients being treated for well-differentiated STS-E. While the use of adjuvant RT may be viewed as a means to facilitate limb salvage, this large national database review confirms no survival benefit, regardless of tumor size or margin status. Copyright ? 2015 Alexander L. Lazarides et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929630315&doi=10.1155%2f2015%2f186581&partnerID=40&md5=0c37b877d6eba7e077b9cc110bbdd296 https://scholars.lib.ntu.edu.tw/handle/123456789/456360 |
ISSN: | 1357-714X | DOI: | 10.1155/2015/186581 | SDG/關鍵字: | adult; aged; cancer adjuvant therapy; cancer radiotherapy; cancer surgery; cancer survival; controlled study; female; follow up; human; limb amputation; limb salvage; limb tumor; long term survival; major clinical study; male; overall survival; priority journal; retrospective study; Review; soft tissue sarcoma; treatment outcome; well differentiated liposarcoma; well differentiated soft tissue sarcoma of the extremity |
顯示於: | 醫學系 |
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