https://scholars.lib.ntu.edu.tw/handle/123456789/460332
標題: | Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration | 作者: | Lee T.-H MING-YIH WU HSIN-FU CHEN MEI-JOU CHEN HONG-NERNG HO YU-SHIH YANG |
公開日期: | 2005 | 卷: | 83 | 期: | 6 | 起(迄)頁: | 1700-1707 | 來源出版物: | Fertility and Sterility | 摘要: | Objective: To determine the efficiency of a single-dose and a multiple-dose protocol for GnRH antagonist administration. Design: Randomized clinical trial. Setting: University hospital, tertiary medical center. Patient(s): Sixty-one patients undergoing controlled ovarian stimulation (COS) and IVF/ICSI. Intervention(s): COS with either a multiple-dose (MD) or a single-dose (SD) protocol for GnRH antagonist (cetrorelix) administration, or with a long protocol (LP) for GnRH agonist (buserelin) administration, followed by oocyte retrieval, IVF/ICSI, and embryo transfer. Main Outcome Measure(s): Follicular development and serum levels of E2 and LH. Result(s): The SD protocol for cetrorelix was associated with a more reduced level of follicular development, lower levels of serum estradiol on the day of HCG administration, and a more reduced number of zygotes than the LP for buserelin. The pregnancy and implantation rates did not differ significantly for the three study groups. Conclusion(s): The MD and SD GnRH antagonist protocols were effective for preventing LH surge and appear to elicit an equivalent pregnancy rate to that corresponding to a LP GnRH agonist. In terms of follicular development, the SD protocol requires further modification, including flexible scheduling or possibly a small reduction of the dosage of the administered cetrorelix. ?2005 by American Society for Reproductive Medicine. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460332 | ISSN: | 0015-0282 | DOI: | 10.1016/j.fertnstert.2004.12.037 | SDG/關鍵字: | buserelin; cetrorelix; chorionic gonadotropin; estradiol; gonadorelin antagonist; human menopausal gonadotropin; luteinizing hormone; progesterone; supromon; adult; article; clinical protocol; clinical trial; controlled clinical trial; controlled study; drug dose reduction; embryo transfer; estradiol blood level; female; female infertility; fertilization in vitro; human; intermethod comparison; intracytoplasmic sperm injection; luteinizing hormone blood level; major clinical study; multiple drug dose; oocyte; ovary; ovary disease; ovary follicle maturation; ovary function; priority journal; randomized controlled trial; sample size; single drug dose; stimulation; zygote; Adult; Analysis of Variance; Chi-Square Distribution; Drug Administration Schedule; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate |
顯示於: | 醫學系 |
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