Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration
Journal
Fertility and Sterility
Journal Volume
83
Journal Issue
6
Pages
1700-1707
Date Issued
2005
Author(s)
Abstract
Objective: To determine the efficiency of a single-dose and a multiple-dose protocol for GnRH antagonist administration. Design: Randomized clinical trial. Setting: University hospital, tertiary medical center. Patient(s): Sixty-one patients undergoing controlled ovarian stimulation (COS) and IVF/ICSI. Intervention(s): COS with either a multiple-dose (MD) or a single-dose (SD) protocol for GnRH antagonist (cetrorelix) administration, or with a long protocol (LP) for GnRH agonist (buserelin) administration, followed by oocyte retrieval, IVF/ICSI, and embryo transfer. Main Outcome Measure(s): Follicular development and serum levels of E2 and LH. Result(s): The SD protocol for cetrorelix was associated with a more reduced level of follicular development, lower levels of serum estradiol on the day of HCG administration, and a more reduced number of zygotes than the LP for buserelin. The pregnancy and implantation rates did not differ significantly for the three study groups. Conclusion(s): The MD and SD GnRH antagonist protocols were effective for preventing LH surge and appear to elicit an equivalent pregnancy rate to that corresponding to a LP GnRH agonist. In terms of follicular development, the SD protocol requires further modification, including flexible scheduling or possibly a small reduction of the dosage of the administered cetrorelix. ?2005 by American Society for Reproductive Medicine.
SDGs
Other Subjects
buserelin; cetrorelix; chorionic gonadotropin; estradiol; gonadorelin antagonist; human menopausal gonadotropin; luteinizing hormone; progesterone; supromon; adult; article; clinical protocol; clinical trial; controlled clinical trial; controlled study; drug dose reduction; embryo transfer; estradiol blood level; female; female infertility; fertilization in vitro; human; intermethod comparison; intracytoplasmic sperm injection; luteinizing hormone blood level; major clinical study; multiple drug dose; oocyte; ovary; ovary disease; ovary follicle maturation; ovary function; priority journal; randomized controlled trial; sample size; single drug dose; stimulation; zygote; Adult; Analysis of Variance; Chi-Square Distribution; Drug Administration Schedule; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Ovarian Follicle; Ovulation Induction; Pregnancy; Pregnancy Rate
Type
journal article