https://scholars.lib.ntu.edu.tw/handle/123456789/468904
Title: | CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features | Authors: | CHUNG-WU LIN Liu T.-Y. SHEE-UAN CHEN Wang K.-T. Medeiros L.J. Hsu S.-M. |
Issue Date: | 2005 | Journal Volume: | 106 | Journal Issue: | 10 | Start page/Pages: | 3567-3574 | Source: | Blood | Abstract: | Most lymphoblastic lymphomas (LBLs) are regarded as neoplasms of immature T cells because they express cytoplasmic CD3 and frequently carry T-cell receptor (TCR) gene rearrangements. Immature natural killer (NK) and T cells, however, have a common bipotent T/NK-cell precursor in the thymus, and NK cells also express cytoplasmic CD3. Thus, some LBLs could arise from immature NK cells. Mature NK cells express 2 CD94 transcripts: 1A, induced by interleukin 15 (IL-15), and 1B constitutively. Because immature NK cells require IL-15 for development, CD94 1A transcripts could be a marker of NK-LBL. To test this hypothesis, we used laser capture microdissection to isolate IL-15 receptor α+ lymphoid cells from the thymus and showed that these cells contained CD94 1A transcripts. We then assessed for CD94 transcripts in 21 cases of LBL that were cytoplasmic CD3+, nuclear terminal deoxynucleotidyl transferase positive (TdT+), and CD56-, consistent with either the T-cell or NK-cell lineage. We found that 7 LBLs expressed CD94 1A transcripts without TCR gene rearrangements, suggesting NK-cell lineage. Patients with NK-LBL were younger than patients with T-LBL (15 years versus 33 years; P = .11) and had a better 2-year survival (100% versus 27%; P < .01). These results improve the current classification of LBL and contribute to our understanding of NK-cell differentiation. ? 2005 by The American Society of Hematology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-27744506865&doi=10.1182%2fblood-2005-02-0519&partnerID=40&md5=df92695c48f412a2ad52e57258a87952 https://scholars.lib.ntu.edu.tw/handle/123456789/468904 |
ISSN: | 0006-4971 | DOI: | 10.1182/blood-2005-02-0519 | SDG/Keyword: | CD3 antigen; CD56 antigen; cd94 1a antigen; CD94 antigen; cell marker; DNA nucleotidylexotransferase; interleukin 15; interleukin 15 receptor; T lymphocyte receptor; unclassified drug; adolescent; adult; aged; antigen expression; article; cell isolation; cell lineage; cell maturation; comparative study; controlled study; disease classification; female; gene rearrangement; genetic transcription; human; human cell; human tissue; infant; laser capture microdissection; lymphatic leukemia; lymphoblastoma; lymphoid cell; male; natural killer cell; newborn; nucleotide sequence; priority journal; receptor gene; stem cell; thymus |
Appears in Collections: | 病理學科所 |
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