https://scholars.lib.ntu.edu.tw/handle/123456789/470862
Title: | Suspected nasopharyngeal carcinoma in three workers with long term exposure to sulphuric acid vapour | Authors: | Ho C.-K. Lo W.C.H. PEI-HSIN HUANG Wu M.-T. Christiani D.C. CHIN-TARNG LIN |
Issue Date: | 1999 | Publisher: | BMJ Publishing Group | Journal Volume: | 56 | Journal Issue: | 6 | Start page/Pages: | 426-428 | Source: | Occupational and Environmental Medicine | Abstract: | Sulphuric acid vapour has been suspected of being an industrial carcinogen. In this study, a cluster is presented of three patients with nasopharyngeal carcinoma (NPC) who worked in the same building of a telecommunications conveyance station in southern Taiwan with long term exposure to sulphuric acid vapour concentrations as high as 0.18 mg/m3. All three workers were diagnosed with NPC within a 5 month period between September 1992, and March 1993. Compared with 19 other healthy workers from the same building, these three workers with NPC had worked significantly longer in this building than had the others (mean (SD) (years): 12.7 (0.6) v 7.4 (4.4); p = 0.01). With an in situ nucleic acid hybridisation and immunostaining method for colocalised Epstein-Barr virus (EBV) and secretory component (SC) protein among biopsy specimens of these three patiente with NPCs, it was found that some tumour cells did not contain EBV and SC protein staining signals. These results indicate that EBV infection is not the only risk factor for NPC and long term exposure to relatively low concentrations of sulphuric acid vapour may be associated with the development of NPC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032957884&doi=10.1136%2foem.56.6.426&partnerID=40&md5=200a9d7c8102e5a2b92875135544f705 https://scholars.lib.ntu.edu.tw/handle/123456789/470862 |
ISSN: | 1351-0711 | DOI: | 10.1136/oem.56.6.426 | SDG/Keyword: | nucleic acid; secretory component; sulfuric acid; adult; article; controlled study; Epstein Barr virus; human; human tissue; immunohistochemistry; major clinical study; nasopharynx carcinoma; nucleic acid hybridization; occupational exposure; priority journal; risk factor; Taiwan; telecommunication; tumor biopsy; Human herpesvirus 4 |
Appears in Collections: | 病理學科所 |
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