https://scholars.lib.ntu.edu.tw/handle/123456789/473527
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tsai C.-Y. | en_US |
dc.contributor.author | KUAN-TING KUO | en_US |
dc.contributor.author | Cheng A.M.S. | en_US |
dc.contributor.author | YI-HSUAN WEI | en_US |
dc.contributor.author | Chang H.-C. | en_US |
dc.contributor.author | Chang K. | en_US |
dc.contributor.author | SHU-LANG LIAO | en_US |
dc.creator | Tsai C.-Y.;Kuan-Ting Kuo;Cheng A.M.S.;Wei Y.-H.;Chang H.-C.;Chang K.;Liao S.-L. | - |
dc.date.accessioned | 2020-03-07T06:42:02Z | - |
dc.date.available | 2020-03-07T06:42:02Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0271-3683 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067550770&doi=10.1080%2f02713683.2019.1627462&partnerID=40&md5=f3e81030806a0da892461ca50ca99b68 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473527 | - |
dc.description.abstract | Purpose: To determine the prevalence, clinical manifestations, and treatment outcomes of IgG4-related ophthalmic disease (IgG4-ROD) in previously diagnosed idiopathic orbital inflammation (IOI). Materials and Methods: Thirty one surgically treated patients with IOI between 1990 and 2015 were divided into sclerosing (SIOI) and non-sclerosing (NSIOI) to identify IgG4-ROD. Preserved pathological specimens were immunostained for IgG4 cells. Changes in clinical features were evaluated before and after treatment. Results: Out of the 31 patients, 15 (48.4%) had IgG4-ROD, consisting of 7 of the 16 SIOI (43.8%) and 8 of the 15 NSIOI patients (53.3%). Among 15 patients with IgG4-ROD, 4 (26.7%) achieved complete remission, which was significantly less than among IgG4-unrelated patients (11/16, 68.8%, p =?.03). Furthermore, 3 out of 15 IgG4-ROD patients (20%) experienced recurrence, all of whom had SIOI, compared to 0% among IgG4-unrelated patients (p =?.1). Conclusions: IgG4-ROD is common among previously identified IOI in our study. Treatment response is modest in IgG4-ROD patients. ? 2019, ? 2019 Taylor & Francis Group, LLC. | - |
dc.publisher | Taylor and Francis Ltd | - |
dc.relation.ispartof | Current Eye Research | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | immunoglobulin G4; methylprednisolone sodium succinate; prednisolone; immunoglobulin G; adult; Article; clinical feature; controlled study; eye disease; female; human; human cell; human tissue; idiopathic disease; immunoglobulin G4 related disease; immunohistochemistry; major clinical study; male; middle aged; orbit inflammation; prevalence; priority journal; recurrent disease; remission; retrospective study; treatment outcome; treatment response; autoimmune disease; follow up; forecasting; immunology; orbit pseudotumor; orbital myositis; Autoimmune Diseases; Follow-Up Studies; Forecasting; Humans; Immunoglobulin G; Immunohistochemistry; Orbital Myositis; Orbital Pseudotumor; Retrospective Studies | - |
dc.title | IgG4-related Ophthalmic Disease in Idiopathic Sclerosing and Non-Sclerosing Orbital Inflammation: A 25-Year Experience | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1080/02713683.2019.1627462 | - |
dc.identifier.pmid | 31154852 | - |
dc.identifier.scopus | 2-s2.0-85067550770 | - |
dc.relation.pages | 1220-1225 | - |
dc.relation.journalvolume | 44 | - |
dc.relation.journalissue | 11 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Oculoplasty and Neuro-Ophthalmology | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Oculoplasty and Neuro-Ophthalmology | - |
crisitem.author.orcid | 0000-0002-3657-1652 | - |
crisitem.author.orcid | 0000-0002-2087-9855 | - |
crisitem.author.orcid | 0000-0002-4312-5351 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
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