https://scholars.lib.ntu.edu.tw/handle/123456789/473527
標題: | IgG4-related Ophthalmic Disease in Idiopathic Sclerosing and Non-Sclerosing Orbital Inflammation: A 25-Year Experience | 作者: | Tsai C.-Y. KUAN-TING KUO Cheng A.M.S. YI-HSUAN WEI Chang H.-C. Chang K. SHU-LANG LIAO |
公開日期: | 2019 | 出版社: | Taylor and Francis Ltd | 卷: | 44 | 期: | 11 | 起(迄)頁: | 1220-1225 | 來源出版物: | Current Eye Research | 摘要: | Purpose: To determine the prevalence, clinical manifestations, and treatment outcomes of IgG4-related ophthalmic disease (IgG4-ROD) in previously diagnosed idiopathic orbital inflammation (IOI). Materials and Methods: Thirty one surgically treated patients with IOI between 1990 and 2015 were divided into sclerosing (SIOI) and non-sclerosing (NSIOI) to identify IgG4-ROD. Preserved pathological specimens were immunostained for IgG4 cells. Changes in clinical features were evaluated before and after treatment. Results: Out of the 31 patients, 15 (48.4%) had IgG4-ROD, consisting of 7 of the 16 SIOI (43.8%) and 8 of the 15 NSIOI patients (53.3%). Among 15 patients with IgG4-ROD, 4 (26.7%) achieved complete remission, which was significantly less than among IgG4-unrelated patients (11/16, 68.8%, p =?.03). Furthermore, 3 out of 15 IgG4-ROD patients (20%) experienced recurrence, all of whom had SIOI, compared to 0% among IgG4-unrelated patients (p =?.1). Conclusions: IgG4-ROD is common among previously identified IOI in our study. Treatment response is modest in IgG4-ROD patients. ? 2019, ? 2019 Taylor & Francis Group, LLC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067550770&doi=10.1080%2f02713683.2019.1627462&partnerID=40&md5=f3e81030806a0da892461ca50ca99b68 https://scholars.lib.ntu.edu.tw/handle/123456789/473527 |
ISSN: | 0271-3683 | DOI: | 10.1080/02713683.2019.1627462 | SDG/關鍵字: | immunoglobulin G4; methylprednisolone sodium succinate; prednisolone; immunoglobulin G; adult; Article; clinical feature; controlled study; eye disease; female; human; human cell; human tissue; idiopathic disease; immunoglobulin G4 related disease; immunohistochemistry; major clinical study; male; middle aged; orbit inflammation; prevalence; priority journal; recurrent disease; remission; retrospective study; treatment outcome; treatment response; autoimmune disease; follow up; forecasting; immunology; orbit pseudotumor; orbital myositis; Autoimmune Diseases; Follow-Up Studies; Forecasting; Humans; Immunoglobulin G; Immunohistochemistry; Orbital Myositis; Orbital Pseudotumor; Retrospective Studies |
顯示於: | 病理學科所 |
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