https://scholars.lib.ntu.edu.tw/handle/123456789/473639
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yap K.L. | en_US |
dc.contributor.author | Hafez M.J. | en_US |
dc.contributor.author | TSUI-LIEN MAO | en_US |
dc.contributor.author | Kurman R.J. | en_US |
dc.contributor.author | Murphy K.M. | en_US |
dc.contributor.author | Shih I.-M. | en_US |
dc.creator | Yap K.L.;Hafez M.J.;Tsui-Lien Mao;Kurman R.J.;Murphy K.M.;Shih I.-M. | - |
dc.date.accessioned | 2020-03-07T06:48:20Z | - |
dc.date.available | 2020-03-07T06:48:20Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1687-8450 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930533354&doi=10.1155%2f2010%2f364508&partnerID=40&md5=1f62d415f0ec619af4b424a830a38ac6 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473639 | - |
dc.description.abstract | Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site trophoblastic tumors (PSTTs) and epithelioid trophoblastic tumors (ETTs). Since these tumors are derivatives of fetal trophoblastic tissue, approximately 50% of GTN cases are expected to originate from a male conceptus and carry a Y-chromosomal complement according to a balanced sex ratio. To investigate this hypothesis, we carried out a comprehensive analysis by genotyping a relatively large sample size of 51 GTN cases using three independent sex chromosome genetic markers; Amelogenin, Protein Kinase and Zinc Finger have X and Y homologues that are distinguishable by their PCR product size. We found that all cases contained the X-chromosomal complement while only five (10%) of 51 tumors harbored the Y-chromosomal complement. Specifically, Y-chromosomal signals were detected in one (5%) of 19 choriocarcinomas, one (7%) of 15 PSTTs and three (18%) of 17 ETTs. The histopathological features of those with a Y-chromosome were similar to those without. Our results demonstrate the presence of a Y-chromosomal complement in GTNs, albeit a low 10% of cases. This shortfall of Y-chromosomal complements in GTNs may reinforce the notion that the majority of GTNs are derived from previous molar gestations. Copyright ? 2010 Kai Lee Yap et al. | - |
dc.publisher | Hindawi Limited | - |
dc.relation.ispartof | Journal of Oncology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amelogenin; protein kinase; zinc finger protein; Article; choriocarcinoma; female; genetic marker; genotype; histopathology; human; human tissue; polymerase chain reaction; syncytiotrophoblast cell; trophoblast; trophoblastic tumor; X chromosome; Y chromosome | - |
dc.title | Lack of a Y-chromosomal complement in the majority of gestational trophoblastic neoplasms | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1155/2010/364508 | - |
dc.identifier.scopus | 2-s2.0-84930533354 | - |
dc.relation.pages | 364508 | - |
dc.relation.journalvolume | 2010 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0002-0159-3691 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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