https://scholars.lib.ntu.edu.tw/handle/123456789/473639
標題: | Lack of a Y-chromosomal complement in the majority of gestational trophoblastic neoplasms | 作者: | Yap K.L. Hafez M.J. TSUI-LIEN MAO Kurman R.J. Murphy K.M. Shih I.-M. |
公開日期: | 2010 | 出版社: | Hindawi Limited | 卷: | 2010 | 起(迄)頁: | 364508 | 來源出版物: | Journal of Oncology | 摘要: | Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site trophoblastic tumors (PSTTs) and epithelioid trophoblastic tumors (ETTs). Since these tumors are derivatives of fetal trophoblastic tissue, approximately 50% of GTN cases are expected to originate from a male conceptus and carry a Y-chromosomal complement according to a balanced sex ratio. To investigate this hypothesis, we carried out a comprehensive analysis by genotyping a relatively large sample size of 51 GTN cases using three independent sex chromosome genetic markers; Amelogenin, Protein Kinase and Zinc Finger have X and Y homologues that are distinguishable by their PCR product size. We found that all cases contained the X-chromosomal complement while only five (10%) of 51 tumors harbored the Y-chromosomal complement. Specifically, Y-chromosomal signals were detected in one (5%) of 19 choriocarcinomas, one (7%) of 15 PSTTs and three (18%) of 17 ETTs. The histopathological features of those with a Y-chromosome were similar to those without. Our results demonstrate the presence of a Y-chromosomal complement in GTNs, albeit a low 10% of cases. This shortfall of Y-chromosomal complements in GTNs may reinforce the notion that the majority of GTNs are derived from previous molar gestations. Copyright ? 2010 Kai Lee Yap et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930533354&doi=10.1155%2f2010%2f364508&partnerID=40&md5=1f62d415f0ec619af4b424a830a38ac6 https://scholars.lib.ntu.edu.tw/handle/123456789/473639 |
ISSN: | 1687-8450 | DOI: | 10.1155/2010/364508 | SDG/關鍵字: | amelogenin; protein kinase; zinc finger protein; Article; choriocarcinoma; female; genetic marker; genotype; histopathology; human; human tissue; polymerase chain reaction; syncytiotrophoblast cell; trophoblast; trophoblastic tumor; X chromosome; Y chromosome |
顯示於: | 病理學科所 |
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