https://scholars.lib.ntu.edu.tw/handle/123456789/473712
標題: | Malignant fat-forming solitary fibrous tumor (so-called "lipomatous hemangiopericytoma"): Clinicopathologic analysis of 14 cases | 作者: | JEN-CHIEH LEE Fletcher C.D.M. |
公開日期: | 2011 | 卷: | 35 | 期: | 8 | 起(迄)頁: | 1177-1185 | 來源出版物: | American Journal of Surgical Pathology | 摘要: | Fat-forming solitary fibrous tumor is a rare variant of solitary fibrous tumor (SFT). Generally regarded as benign, very few fat-forming SFTs with malignant histologic features have been reported. Here, we report 14 histologically malignant fat-forming SFTs to better characterize this subset. Seven patients were female and 7 were male, with ages ranging 20 to 93 years (median, 57 y). Five tumors were located in the lower limb, 3 in the trunk, 3 in abdominopelvic locations, 2 in the head and neck region, and 1 in the upper limb. The tumor size ranged from 3.4 to 20 cm (median, 8.6 cm). Histologically, all exhibited at least focal hypercellularity; 12 tumors had mitoses >4/10 high-power fields (range, 2 to 37; median, 8), 12 showed at least moderate atypia, and 8 showed necrosis. It should be noted that 7 tumors contained only mature adipose tissue, whereas 5 contained multivacuolated lipoblasts and 2 had areas resembling atypical lipomatous tumor (ALT). Immunohistochemically, CD34 and CD99 were positive in most cases (11 of 14 and 8 of 10, respectively); MDM2 and CDK4 were both negative in all 4 cases tested (including both tumors with ALT-like areas). Follow-up data from 10 cases (median duration, 47.5 mo; range, 5 to 76) showed 2 patients with multiple metastases (both to lung and bones, and 1 each to breast and to soft tissue), both of whom died of disease. In conclusion, fat-forming SFTs exhibiting malignant histologic features have potential for aggressive behavior. The presence of lipoblasts and/or ALT-like areas, although described in some "benign" examples of fat-forming SFT, seems much more common in the malignant subset and may prompt a careful search for morphologic evidence of malignancy in any case of fat-forming SFT. Copyright ? 2011 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79961027006&doi=10.1097%2fPAS.0b013e318219cd0b&partnerID=40&md5=139e4d830a2321766b61d3e7a79747a3 https://scholars.lib.ntu.edu.tw/handle/123456789/473712 |
ISSN: | 0147-5185 | DOI: | 10.1097/PAS.0b013e318219cd0b | SDG/關鍵字: | tumor marker; abdominal tumor; adult; aged; article; biopsy; chemistry; female; head and neck tumor; hemangiopericytoma; human; immunohistochemistry; limb; lipoma; male; metastasis; middle aged; mortality; pathology; rectum tumor; soft tissue tumor; solitary fibrous tumor; time; treatment outcome; Abdominal Neoplasms; Adult; Aged; Aged, 80 and over; Biopsy; Extremities; Female; Head and Neck Neoplasms; Hemangiopericytoma; Humans; Immunohistochemistry; Lipoma; Male; Middle Aged; Rectal Neoplasms; Soft Tissue Neoplasms; Solitary Fibrous Tumors; Time Factors; Treatment Outcome; Tumor Markers, Biological; Young Adult |
顯示於: | 病理學科所 |
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