https://scholars.lib.ntu.edu.tw/handle/123456789/473954
Title: | E-Cadherin expression in surgically-resected non-small cell lung cancers - A clinicopathological study | Authors: | Lee Y.-C. CHEN-TU WU Luh S.-P. JANG-MING LEE Chen C.-S. YIH-LEONG CHANG |
Issue Date: | 2000 | Journal Volume: | 48 | Journal Issue: | 5 | Start page/Pages: | 294-299 | Source: | Thoracic and Cardiovascular Surgeon | Abstract: | Background: E-Cadherin is a subclass of the cadherin family that plays a major role in the maintenance of intercellular junctions in normal epithelium. Decreased expression of E-cadherin might be closely related to invasiveness and dedifferentiation in human cancers. This study is aimed at investigating the clinicopathological significance of E-cadherin expression and its impact on the prognosis in surgically resected non-small-cell lung cancer patients. Methods: Using immunohistochemical staining, the expression of E-cadherin was studied in 207 surgically resected lung cancer specimens from January 1990 through December 1994. The clinicopathological data and survival status were recorded and analysed against the E-cadherin expression level in each tumor. Results: E-cadherin expression was detected in 122 of the 207 lung tumors (59.0%), and the expression was significantly lower in tumors with poor differentiation (p < 0.001), in tumors with vascular invasion (p < 0.05), and in tumors with direct invasion into surrounding structures (p < 0.01). There was no correlation between E-cadherin expression, and tumor stage and regional lymph-node metastasis. There was no significant difference in survival rate between higher (> 40%) and lower (< 40%) E-cadherin expression groups; however, in tumors 3 cm or less, a significant difference was found between higher and lower E-cadherin expressions (p < 0.0001). Conclusions: Underexpression of E-cadherin is associated with poor differentiation and invasiveness in NSCLC. In patients with small NSCLC (? 3 cm), higher E-cadherin expression (> 40%) significantly had a favorable prognosis. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033790650&doi=10.1055%2fs-2000-7885&partnerID=40&md5=2b1c520fdd9c40349deff405230e3aec https://scholars.lib.ntu.edu.tw/handle/123456789/473954 |
ISSN: | 0171-6425 | DOI: | 10.1055/s-2000-7885 | SDG/Keyword: | uvomorulin; adult; aged; article; cancer invasion; cancer staging; cell differentiation; cell junction; female; human; human tissue; immunohistochemistry; lung non small cell cancer; lymph node metastasis; major clinical study; male; pathology; priority journal; prognosis; protein expression; protein family; survival rate; tumor volume; Adult; Aged; Aged, 80 and over; Biological Markers; Cadherins; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Survival Rate |
Appears in Collections: | 病理學科所 |
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