https://scholars.lib.ntu.edu.tw/handle/123456789/475239
標題: | Asthma: Environmental Risk Factors | 作者: | CHI-HSIEN CHEN Yue Leon Guo |
關鍵字: | Air pollution; Asthma; Environmental intervention; Indoor air; Irritant; Occupational; Sensitizer | 公開日期: | 2011 | 出版社: | Elsevier Inc. | 起(迄)頁: | 238-246 | 來源出版物: | Encyclopedia of Environmental Health | 摘要: | Asthma is an allergic disease inducing chronic airway inflammation and acute attacks. Asthma not only decreases the quality of life, but also leads to life-threatening events in severe cases. The increasing prevalence of asthma is a worldwide trend both in children and adults. In the past few years, environmental interventions for asthma are shown to provide additional benefit beyond medical therapies. This article summarizes current evidences of environmental risks for asthma. The environmental factors include indoor, outdoor, and occupational agents, which are grouped into sensitizers and irritants. The sensitizers cause and trigger asthma activity through the allergic immunization process. Once human beings are sensitized, very low concentration of the specific sensitizers can evoke asthma attack. The irritants damage and stimulate airway mucosa directly without a sensitizing period. Environment-environment interactions exist due to the fact that sensitized airways are hyperresponsive to irritants, and that irritant-damaged mucosa is prone to the penetration of sensitizers. The sources and mechanisms of environmental agents causing asthma, as well as strategies for environmental prevention and remediation of risk factors are discussed in this article. ? 2011 Elsevier B.V. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856232174&doi=10.1016%2fB978-0-444-52272-6.00447-5&partnerID=40&md5=34a923afdf5430ac0ba06047ff308b81 https://scholars.lib.ntu.edu.tw/handle/123456789/475239 |
ISBN: | 9780444522726 | DOI: | 10.1016/B978-0-444-52272-6.00447-5 |
顯示於: | 環境職業醫學科 |
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