https://scholars.lib.ntu.edu.tw/handle/123456789/481003
Title: | Study of poly-ɛ-caprolactone membranes for pleurodesis | Authors: | KE-CHENG CHEN MIN-SHU HSIEH Li, Yun-Ru Lin, Yong-Chong HONG-SHIEE LAI MING-JIUM SHIEH JIN-SHING CHEN Tai-Horng Young |
Issue Date: | 2017 | Publisher: | Elsevier B.V. | Journal Volume: | 116 | Journal Issue: | 11 | Start page/Pages: | 880-887 | Source: | Journal of the Formosan Medical Association | Abstract: | Background/Purpose Pleurodesis with biomaterial membrane is an emerging treatment method for pneumothorax. However, the ideal one for the common disease is still under debate. Methods We investigate the Poly-ε-caprolactone (PCL) membrane pleurodesis by using New Zealand White rabbits, which was sacrificed for examination one month later. Moreover, inflammation and fibrosis scoring were done under microscopic evaluation, as well as Western blot analysis in vitro and in vivo. Results Gross evaluation of pleurodesis score revealed that dense PCL membrane produced moderate pleural adhesion, while porous PCL membrane exhibited significantly higher pleurodesis scores. Conclusion PCL membrane induced significant degree of adhesion, both within the abdomen and chest of the rabbits. The porous PCL membrane produces more intensive adhesion than dense one. Fibronectin plays an important role in the process of pleurodesis. Further study is required for the clinical application of the promising material. ? 2017 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012911822&doi=10.1016%2fj.jfma.2016.12.009&partnerID=40&md5=3220abccb1547497eba1db9bc0d420d1 https://scholars.lib.ntu.edu.tw/handle/123456789/481003 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2016.12.009 | SDG/Keyword: | polycaprolactone; polycaprolactone; polyester; animal experiment; animal model; Article; controlled study; human; human cell; in vitro study; in vivo study; inflammation; lung fibrosis; male; membrane; microscopy; nonhuman; pilot study; pleurodesis; rat; scoring system; Western blotting; animal; artificial membrane; C57BL mouse; cell line; Leporidae; materials testing; mouse; pleurodesis; pneumothorax; procedures; Animals; Cell Line; Humans; Male; Materials Testing; Membranes, Artificial; Mice; Mice, Inbred C57BL; Pleurodesis; Pneumothorax; Polyesters; Rabbits |
Appears in Collections: | 醫學系 |
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