https://scholars.lib.ntu.edu.tw/handle/123456789/495428
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | WEI-YIH CHIU | en_US |
dc.contributor.author | WEI-SHIUNG YANG | en_US |
dc.contributor.author | JUNG-YIEN CHIEN | en_US |
dc.contributor.author | JANG-JAER LEE | en_US |
dc.contributor.author | KEH-SUNG TSAI | en_US |
dc.creator | Tsai K.-S.;Lee J.-J.;Chien J.-Y.;Yang W.-S.;WEI-YIH CHIU | - |
dc.date.accessioned | 2020-06-01T03:27:12Z | - |
dc.date.available | 2020-06-01T03:27:12Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045924636&doi=10.1371%2fjournal.pone.0196419&partnerID=40&md5=bdbe55834b687c9551b2900f6587056e | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/495428 | - |
dc.description.abstract | Background Although bisphosphonate-related osteonecrosis of the jaw (ONJ) develops mainly after tooth extractions (TEs), the strength of the association between them and how the existence of the disease among bisphosphonate (BP)-treated osteoporotic patients exposed to TE remain uncertain. Methods A nationwide retrospective cohort study investigated the influence of alendronate and TE on the development of ONJ. Results Incidence of ONJ following long-term alendronate therapy was 262/100,000 person-years, while no event developed in the control group on raloxifene. Overall prevalence of ONJ in osteoporotic subjects receiving alendronate was estimated at 0.34% which rose to 2.16% after TE. Multiple logistic regression analysis, adjusted for the potential confounders, showed TE (adjusted odds ratio, 9.60 [4.33–21.29]), drug duration exceeding 3 years (3.00 [1.33–6.76]), and concomitant rheumatoid arthritis (4.94 [1.64–14.90]) were independent predictors of ONJ. Conclusions This article strengthens the relationship between ONJ and BPs. Among osteoporotic patients exposed to alendronate, TE confers a 9.6-fold increased risk for ONJ and it should be performed with caution irrespective of drug duration. ? 2018 Chiu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.publisher | Public Library of Science | - |
dc.relation.ispartof | PLoS ONE | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alendronic acid; raloxifene; alendronic acid; bone density conservation agent; raloxifene; aged; Article; cohort analysis; controlled study; female; human; incidence; jaw osteonecrosis; long term care; major clinical study; male; osteoporosis; prevalence; retrospective study; rheumatoid arthritis; risk factor; tooth extraction; treatment duration; jaw osteonecrosis; middle aged; odds ratio; osteoporosis; pathology; statistical model; tooth extraction; Aged; Alendronate; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Osteoporosis; Prevalence; Raloxifene Hydrochloride; Retrospective Studies; Tooth Extraction | - |
dc.title | The influence of alendronate and tooth extraction on the incidence of osteonecrosis of the jaw among osteoporotic subjects | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0196419 | - |
dc.identifier.pmid | 29694412 | - |
dc.identifier.scopus | 2-s2.0-85045924636 | - |
dc.relation.pages | e0196419 | - |
dc.relation.journalvolume | 13 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHYL | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-3124-7121 | - |
crisitem.author.orcid | 0000-0001-5087-373X | - |
crisitem.author.orcid | 0000-0002-7718-0594 | - |
crisitem.author.orcid | 0000-0003-0964-0840 | - |
crisitem.author.orcid | 0000-0001-8528-1566 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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