https://scholars.lib.ntu.edu.tw/handle/123456789/495428
Title: | The influence of alendronate and tooth extraction on the incidence of osteonecrosis of the jaw among osteoporotic subjects | Authors: | WEI-YIH CHIU WEI-SHIUNG YANG JUNG-YIEN CHIEN JANG-JAER LEE KEH-SUNG TSAI |
Issue Date: | 2018 | Publisher: | Public Library of Science | Journal Volume: | 13 | Journal Issue: | 4 | Start page/Pages: | e0196419 | Source: | PLoS ONE | Abstract: | Background Although bisphosphonate-related osteonecrosis of the jaw (ONJ) develops mainly after tooth extractions (TEs), the strength of the association between them and how the existence of the disease among bisphosphonate (BP)-treated osteoporotic patients exposed to TE remain uncertain. Methods A nationwide retrospective cohort study investigated the influence of alendronate and TE on the development of ONJ. Results Incidence of ONJ following long-term alendronate therapy was 262/100,000 person-years, while no event developed in the control group on raloxifene. Overall prevalence of ONJ in osteoporotic subjects receiving alendronate was estimated at 0.34% which rose to 2.16% after TE. Multiple logistic regression analysis, adjusted for the potential confounders, showed TE (adjusted odds ratio, 9.60 [4.33–21.29]), drug duration exceeding 3 years (3.00 [1.33–6.76]), and concomitant rheumatoid arthritis (4.94 [1.64–14.90]) were independent predictors of ONJ. Conclusions This article strengthens the relationship between ONJ and BPs. Among osteoporotic patients exposed to alendronate, TE confers a 9.6-fold increased risk for ONJ and it should be performed with caution irrespective of drug duration. ? 2018 Chiu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045924636&doi=10.1371%2fjournal.pone.0196419&partnerID=40&md5=bdbe55834b687c9551b2900f6587056e https://scholars.lib.ntu.edu.tw/handle/123456789/495428 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0196419 | SDG/Keyword: | alendronic acid; raloxifene; alendronic acid; bone density conservation agent; raloxifene; aged; Article; cohort analysis; controlled study; female; human; incidence; jaw osteonecrosis; long term care; major clinical study; male; osteoporosis; prevalence; retrospective study; rheumatoid arthritis; risk factor; tooth extraction; treatment duration; jaw osteonecrosis; middle aged; odds ratio; osteoporosis; pathology; statistical model; tooth extraction; Aged; Alendronate; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Osteoporosis; Prevalence; Raloxifene Hydrochloride; Retrospective Studies; Tooth Extraction |
Appears in Collections: | 醫學系 |
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