https://scholars.lib.ntu.edu.tw/handle/123456789/496623
Title: | In vivo evidence of duality effects for lovastatin in a nude mouse cancer model | Authors: | CHIH-YUAN WANG Shui H.-A. TIEN-CHUN CHANG |
Issue Date: | 2010 | Journal Volume: | 126 | Journal Issue: | 2 | Start page/Pages: | 578-582 | Source: | International Journal of Cancer | Abstract: | Statins, hydroxy-methyl-glutaryl coenzyme A reductase inhibitors, are the most effective medication for lowering cholesterol, cardiovascular morbidity and mortality. On the basis of our previous in vitro experimental results on an anaplastic thyroid cancer cell line, we designed a nude mouse model in which cancer cells were seeded subcutaneously to examine the potential anticancer effects of lovastatin in vivo. As expected, tumor growth was significantly reduced in the mice treated with 5 or 10 mg/kg/day of lovastatin compared with the positive control group. However, the tumor grew much faster in the mice treated with 1 mg/kg/day of lovastatin than in the positive control group. We suspect this result might be related to vascular endothelial growth factor. In this model, we found that lovastatin inhibits tumor growth at a high dosage (5 or 10 mg/kg/day), suggesting it could be used as an effectively adjuvant chemotherapy for cancer. However, it also promotes tumor growth at a low dosage (1 mg/kg/day). This duality effect should be further studied for patients treated with various dosages of statins. ? 2009 UICC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-73549085851&doi=10.1002%2fijc.24760&partnerID=40&md5=cc8b0b3d1db572581deb73072693be8e https://scholars.lib.ntu.edu.tw/handle/123456789/496623 |
ISSN: | 0020-7136 | DOI: | 10.1002/ijc.24760 | SDG/Keyword: | mevinolin; vasculotropin; animal experiment; animal model; animal tissue; antineoplastic activity; article; cancer cell culture; cancer inhibition; cancer model; controlled study; drug dose comparison; drug effect; drug efficacy; drug megadose; human; human cell; in vivo study; low drug dose; mouse; nonhuman; nude mouse; priority journal; thyroid cancer; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Lovastatin; Mice; Mice, Inbred BALB C; Mice, Nude; Receptors, Vascular Endothelial Growth Factor; Thyroid Neoplasms; Treatment Outcome; Tumor Burden; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays |
Appears in Collections: | 醫學系 |
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