https://scholars.lib.ntu.edu.tw/handle/123456789/510020
標題: | Incorrect diagnoses in patients with neutralizing anti-interferon-gamma-autoantibodies | 作者: | UN-IN WU JANN-TAY WANG WANG-HUEI SHENG HSIN-YUN SUN ARISTINE CHENG Hsu, L. Y. SHAN-CHWEN CHANG YEE-CHUN CHEN |
關鍵字: | Adult-onset immunodeficiency | Disseminated non-tuberculous mycobacterial infections | Incorrect diagnoses | metastatic carcinoma | Neutralizing anti-interferon-gamma-autoantibodies | TB;Adult-onset immunodeficiency; Disseminated non-tuberculous mycobacterial infections; Incorrect diagnoses; metastatic carcinoma; Neutralizing anti-interferon-gamma-autoantibodies; TB | 公開日期: | 1-一月-2020 | 來源出版物: | Clinical Microbiology and Infection | 摘要: | © 2020 Objectives: Early diagnosis of adult-onset immunodeficiency associated with neutralizing anti-interferon-gamma autoantibodies (anti-IFNγ Abs) remains difficult given the lack of a distinctive phenotype and a routine test. This study aimed to investigate the determinants of incorrect tentative diagnoses and useful clues for early disease recognition. Methods: This study enrolled adult patients who had unexplained opportunistic infections diagnosed at six hospitals and identified those having neutralizing anti-IFNγ Abs (cases). Demographics, medical history, initial presentations and laboratory data, causative pathogens, tentative diagnoses, and treatment were analysed and compared among individuals having neutralizing anti-IFNγ Abs (cases) and those without (controls). Results: Among the 154 patients enrolled, neutralizing anti-IFN-γ Abs were detected in 50 (71%) of 70 patients with disseminated non-tuberculous mycobacterial infection (dNTM) but not in 84 patients without dNTM. The median time from disease onset to the recognition of dNTM associated with neutralizing anti-IFNγ Abs was 1.6 years (range, 0.25–19 years). Incorrect tentative diagnoses resulted in the administration of anti-tuberculosis regimens (60%, 30/50), immunosuppressants (48%, 24/50), and systemic chemotherapy (2%, 10/50) to the 50 cases. Multivariate analysis revealed that case patients were more likely than controls to present with multiple bone lesions (adjusted odds ratio (OR), 27.16; 95% confidence interval (CI), 1.21–609.59) and leukocytosis (adjusted OR, 1.48; 95% CI, 1.12–1.95); however, the controls had a higher rate of mycobacterial bloodstream infection (adjusted OR, 0.05; 95% CI 0.00–0.66). Conclusions: The high rate of incorrect tentative diagnoses led to frequent inappropriate management in patients with neutralizing anti-IFNγ Abs, and highlighted the need for increased awareness among clinicians. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/510020 | ISSN: | 1198743X | DOI: | 10.1016/j.cmi.2020.02.030 | SDG/關鍵字: | autoantibody; gamma interferon antibody; immunosuppressive agent; neutralizing antibody; tuberculostatic agent; autoantibody; gamma interferon; neutralizing antibody; adult; aged; antibody detection; Article; atypical mycobacteriosis; bloodstream infection; bone lesion; chemotherapy; clinical feature; comparative study; connective tissue disease; controlled study; data analysis software; demography; diagnostic error; disseminated non tuberculous mycobacterial infection; early diagnosis; enzyme linked immunosorbent assay; female; fever; human; idiopathic disease; immunoglobulin G4 related disease; leukemia; leukocytosis; lymphadenopathy; lymphoma; major clinical study; male; metastasis; multicenter study; multiple fracture; opportunistic infection; priority journal; prospective study; rheumatoid arthritis; skin defect; systemic lupus erythematosus; systemic therapy; Taiwan; tuberculosis; wasting syndrome; blood; diagnostic error; immune deficiency; immunology; middle aged; very elderly; Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing; Autoantibodies; Diagnostic Errors; Female; Humans; Immunologic Deficiency Syndromes; Interferon-gamma; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Opportunistic Infections; Prospective Studies |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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