https://scholars.lib.ntu.edu.tw/handle/123456789/510931
Title: | Hyperuricemia Associated With Rapid Renal Function Decline in Elderly Taiwanese Subjects | Authors: | CHUNG-JEN YEN CHIH-KANG CHIANG Ho L.-C. SANDY HUEY-JEN HSU KUAN-YU HUNG KWAN-DUN WU TUN-JUN TSAI |
Issue Date: | 2009 | Journal Volume: | 108 | Journal Issue: | 12 | Start page/Pages: | 921-928 | Source: | Journal of the Formosan Medical Association | Abstract: | Background/Purpose: Hyperuricemia is encountered frequently in patients with chronic kidney disease (CKD). We tested the hypothesis that uric acid influences glomerular filtration rate (GFR) and is associated with renal function decline in elderly Taiwanese subjects. Methods: We enrolled 800 elderly Taiwanese subjects for a health checkup. Estimated GFR (eGFR) was measured using the Modification of Diet in Renal Disease Study equation. eGFR < 60 mL/min/1.73 m2 was used to analyze the prevalence and incidence of CKD. Significant renal function decline was defined as a decrease in eGFR of ? 3 mL/min/1.73 m2 per year. Results: The prevalence of CKD was 18.0% in the elderly subjects. Mean serum uric acid level was 6.6 mg/dL in male and 5.6 mg/dL in female subjects, and eGFR was 71.7 mL/min/1.73 m2. Uric acid levels were associated independently and negatively with eGFR after adjusting for conventional factors of renal function decline. One hundred and sixty-two individuals (31.2%) had a significant decline in renal function. As uric acid level increased by 1 mg/dL, the odds of a significant eGFR decline increased by 1.208. Conclusion: Serum uric acid level was associated with eGFR and decline in renal function in elderly Taiwanese subjects. Whether hypouricemic therapy could retard the progression of CKD deserves further in-depth study. ? 2009 Formosan Medical Association & Elsevier. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/510931 | ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(10)60004-6 | SDG/Keyword: | uric acid; aged; article; chronic kidney disease; controlled study; disease association; female; glomerulus filtration rate; human; hyperuricemia; kidney function; major clinical study; male; morbidity; prevalence; Taiwan; uric acid blood level; Aged; Aged, 80 and over; Chronic Disease; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Kidney; Kidney Diseases; Male |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
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