Hyperuricemia Associated With Rapid Renal Function Decline in Elderly Taiwanese Subjects
Journal
Journal of the Formosan Medical Association
Journal Volume
108
Journal Issue
12
Pages
921-928
Date Issued
2009
Author(s)
Abstract
Background/Purpose: Hyperuricemia is encountered frequently in patients with chronic kidney disease (CKD). We tested the hypothesis that uric acid influences glomerular filtration rate (GFR) and is associated with renal function decline in elderly Taiwanese subjects. Methods: We enrolled 800 elderly Taiwanese subjects for a health checkup. Estimated GFR (eGFR) was measured using the Modification of Diet in Renal Disease Study equation. eGFR < 60 mL/min/1.73 m2 was used to analyze the prevalence and incidence of CKD. Significant renal function decline was defined as a decrease in eGFR of ? 3 mL/min/1.73 m2 per year. Results: The prevalence of CKD was 18.0% in the elderly subjects. Mean serum uric acid level was 6.6 mg/dL in male and 5.6 mg/dL in female subjects, and eGFR was 71.7 mL/min/1.73 m2. Uric acid levels were associated independently and negatively with eGFR after adjusting for conventional factors of renal function decline. One hundred and sixty-two individuals (31.2%) had a significant decline in renal function. As uric acid level increased by 1 mg/dL, the odds of a significant eGFR decline increased by 1.208. Conclusion: Serum uric acid level was associated with eGFR and decline in renal function in elderly Taiwanese subjects. Whether hypouricemic therapy could retard the progression of CKD deserves further in-depth study. ? 2009 Formosan Medical Association & Elsevier.
SDGs
Other Subjects
uric acid; aged; article; chronic kidney disease; controlled study; disease association; female; glomerulus filtration rate; human; hyperuricemia; kidney function; major clinical study; male; morbidity; prevalence; Taiwan; uric acid blood level; Aged; Aged, 80 and over; Chronic Disease; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Kidney; Kidney Diseases; Male
Type
journal article