https://scholars.lib.ntu.edu.tw/handle/123456789/512484
標題: | Impact of non-tuberculous mycobacteria on pulmonary function decline in chronic obstructive pulmonary disease | 作者: | CHUN-TA HUANG Tsai Y.-J. HUEY-DONG WU JANN-YUAN WANG CHONG-JEN YU LI-NA LEE PAN-CHYR YANG |
公開日期: | 2012 | 卷: | 16 | 期: | 4 | 起(迄)頁: | 539-545 | 來源出版物: | International Journal of Tuberculosis and Lung Disease | 摘要: | OBJECTIVE: Although chronic obstructive pulmonary disease (COPD) is a common form of structural lung disease associated with pulmonary non-tuberculous mycobacteria (NTM) infection, no longitudinal studies have investigated the role of NTM in COPD disease progression. DESIGN: From 2000 to 2008, spirometry-confirmed COPD patients with sputum specimens sent for mycobacterial cultures were included. Analysis of clinical, microbiological and pulmonary function data was performed. RESULTS: The 251 patients were divided into three groups according to the number of NTM isolates: multiple (n = 47), single (n = 63), and no (n = 141) isolates. Mycobacterium avium complex was the most common species in multiple isolates (36.2%) and single isolate (28.6%) groups. Overall, 24.7% of COPD patients had been admitted for exacerbations at least once a year, and patients with multiple and single NTM isolates were more than twice as likely as those with no isolate to experience such exacerbations (38.3% vs. 31.7% vs. 17.0%). After controlling for confounders, patients with multiple NTM isolates had a greater decline in forced expiratory volume in one second than those with single or no isolates (-79.4 ± 32.8 ml vs. -61.6 ±31.9 ml and -56.2 ± 31.5 ml). CONCLUSION: This study suggests that NTM may play a role in disease progression and deterioration of pulmonary function in COPD patients. ? 2012 The Union. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863356932&doi=10.5588%2fijtld.11.0412&partnerID=40&md5=2642a17ab1fc2d406c5cf639db81c91a https://scholars.lib.ntu.edu.tw/handle/123456789/512484 |
ISSN: | 1027-3719 | DOI: | 10.5588/ijtld.11.0412 | SDG/關鍵字: | amikacin; cilastatin plus imipenem; ciprofloxacin; clarithromycin; ethambutol; isoniazid; levofloxacin; moxifloxacin; rifampicin; aged; article; atypical Mycobacterium; bacterium isolate; chronic obstructive lung disease; controlled study; deterioration; disease course; disease exacerbation; female; follow up; forced expiratory volume; human; lung function; major clinical study; male; Mycobacterium chelonei; Mycobacterium fortuitum; Mycobacterium intracellulare avium; Mycobacterium kansasii; priority journal; spirometry; sputum culture; Aged; Aged, 80 and over; Disease Progression; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Sputum |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。