https://scholars.lib.ntu.edu.tw/handle/123456789/514249
標題: | Hepatic ADC value correlates with cirrhotic severity of patients with biliary atresia | 作者: | Mo Y.H. Jaw F.S. MING-CHIH HO Wang Y.C. STEVEN SHINN-FORNG PENG |
公開日期: | 2011 | 卷: | 80 | 期: | 3 | 起(迄)頁: | e253-e257 | 來源出版物: | European Journal of Radiology | 摘要: | Introduction: At least 40% of survivors of biliary atresia have progressive cirrhosis even after undergoing Kasai operation. The values of hepatic apparent diffusion coefficient and apparent-diffusion-coefficient-related indices were applied to biliary atresia patients and correlated with cirrhotic severity scores of model for end-stage liver disease or pediatric end-stage liver disease model, Child-Turcotte, and Child-Pugh systems. Materials and methods: Thirty-three biliary atresia patents (mean = 1140, 61-4314 days of age) received magnetic resonance image examinations due to complications of biliary atresia from April 2008 to August 2009. Two non-breath-hold diffusion weighted imaging sequences were performed with motion-probing gradients in three directions with two b values: 0/100 and 0/500 s/mm 2; 1000 ms/61.1 ms, time to repeat/time to echo; number of excitation, 1.0; 8 mm section thickness; 40 cm × 40 cm field of view; 128 × 256 matrix in all biliary atresia patients and 18 control subjects. We used the Spearman rank correlation test to analyze the relationship among the scores of model for end-stage liver disease or pediatric end-stage liver disease model, Child-Turcotte and Child-Pugh scores and right hepatic apparent diffusion coefficients, apparent diffusion coefficient using b factor of 500-albumin product and alanine transaminase/apparent diffusion coefficient with b factor of 500 ratio. Results: The right hepatic apparent diffusion coefficient using b factor of 100, apparent diffusion coefficient with b factor of 500 and product of apparent diffusion coefficient with b factor of 500-albumin level were significantly negatively correlated (p ? 0.0125) with model for end-stage liver disease or pediatric end-stage liver disease model, Child-Turcotte, and Child-Pugh scores of biliary atresia patients. The ratio of alanine transaminase level/right hepatic apparent diffusion coefficient with b factor of 500 was also significantly (p ? 0.0251), moderately correlated with Child-Turcotte and Child-Pugh scores (rho = 0.5256 and 0.7518, respectively). Conclusion: Right hepatic apparent diffusion coefficient with b factor of 500 and alanine transaminase/right hepatic apparent diffusion coefficient with b factor of 500 can be useful for long-term follow-up of cirrhotic severity in biliary atresia patients. ? 2010 Elsevier Ireland Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514249 | ISSN: | 0720-048X | DOI: | 10.1016/j.ejrad.2010.11.002 | SDG/關鍵字: | alanine aminotransferase; albumin; apparent diffusion coefficient; article; bile duct atresia; child; controlled study; diffusion weighted imaging; disease classification; disease severity; end stage liver disease; excitation; female; human; image analysis; infant; liver cirrhosis; major clinical study; male; nuclear magnetic resonance imaging; preschool child; priority journal; radiological parameters; school child; Algorithms; Biliary Atresia; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Liver Cirrhosis; Magnetic Resonance Imaging; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Statistics as Topic |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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