https://scholars.lib.ntu.edu.tw/handle/123456789/514778
標題: | Total 25-hydroxyvitamin D concentration as a predictor for all-cause death and cardiovascular event risk among ethnic Chinese adults: A cohort study in a Taiwan community | 作者: | KUO-LIONG CHIEN Hsu, Hsiu-Ching Chen, Pei-Chun HUNG-JU LIN TA-CHEN SU Chen, Ming-Fong Lee, Yuan-Teh |
公開日期: | 25-三月-2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 3 | 起(迄)頁: | e0123097 | 來源出版物: | PLoS ONE | 摘要: | Background: Evidence of an inverse association between serum 25-hydoroxyvitamin D [25(OH)D] and the risk of all-cause death and cardiovascular disease from prospective studies is inconsistent. We tested the relationship between 25(OH)D and the risk among adult ethnic Chinese in Taiwan. Methods: We conducted a community-based cohort study of 1816 participants (age 60.2±10.2 yrs, 45.0% women) in the Chin-Shan Community Cardiovascular Cohort Study who were free of cardiovascular diseases at baseline and provided 25(OH)D measurements. Results: During a median 9.6 (interquartile range, 8.8-10.5) years' follow-up period, totally 263 cases developed cardiovascular death events and 559 participants were documented to death from any cause. As 25(OH)D concentration increased, the incidence rates of cardiovascular events and all-cause death decreased progressively. 25(OH)D was inversely associated with all-cause death: the adjusted hazard ratio was 0.49 (95% confidence interval [CI], 0.25-0.97) for the third quartile and a significant J-shape relationship was found. The performance measures by integrated discriminative improvement showed significant improvement after adding 25(OH)D information (0.14%, 95% CI, 0.03-0.31, P=0.050, for all-cause death and 0.32%, 95% CI, 0.02-0.62, P=0.018 for cardiovascular events). Conclusion: These findings suggested a modest inverse association between 25(OH)D and the risk of all-cause death among diabetic participants and a good predictive factor in the community. Further studies to investigate the mechanism of vitamin D role on health effect are warranted. ? 2015 Chien et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926306415&doi=10.1371%2fjournal.pone.0123097&partnerID=40&md5=7a9f203bcc50f03b474a2849f6da5927 https://scholars.lib.ntu.edu.tw/handle/123456789/514778 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0123097 | SDG/關鍵字: | 25 hydroxyvitamin D; C reactive protein; cholesterol; glucose; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; uric acid; 25-hydroxyvitamin D; vitamin D; adult; aged; Article; body mass; cardiovascular risk; Chinese; cholesterol blood level; cohort analysis; concentration (parameters); controlled study; death; diabetes mellitus; diastolic blood pressure; disease association; drinking behavior; female; follow up; glucose blood level; human; hypertension; incidence; insulin blood level; major clinical study; male; middle aged; prediction; prospective study; risk assessment; smoking; systolic blood pressure; Taiwan; uric acid blood level; vitamin blood level; analogs and derivatives; area under the curve; Asian continental ancestry group; blood; Cardiovascular Diseases; cause of death; demography; Kaplan Meier method; mortality; proportional hazards model; receiver operating characteristic; risk factor; Adult; Aged; Area Under Curve; Asian Continental Ancestry Group; Cardiovascular Diseases; Cause of Death; Cohort Studies; Demography; Female; Follow-Up Studies; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Risk Factors; ROC Curve; Taiwan; Vitamin D |
顯示於: | 醫學系 |
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