https://scholars.lib.ntu.edu.tw/handle/123456789/515811
標題: | Dose reduction for the management of indinavir-related toxicity in human immunodeficiency virus type 1-infected patients in Taiwan: Clinical and pharmacokinetic assessment | 作者: | SUNG-CHING PAN SZU-MIN HSIEH CHIEN-CHING HUNG Huang P.-F. Chen M.-Y. SHAN-CHWEN CHANG |
公開日期: | 2005 | 卷: | 38 | 期: | 1 | 起(迄)頁: | 31-34 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | This study evaluated the feasibility of reducing the indinavir (IDV) dosage in Taiwanese patients receiving the standard IDV/ritonavir (RTV) dosage of 800/100 mg twice a day who had undetectable plasma human immunodeficiency virus type 1 (HIV-1) RNA but had developed IDV-related toxicities. After dosage reduction to IDV/RTV 600/100 mg twice a day, the dose-related toxicity decreased and plasma HIV RNA remained undetectable at 24 weeks post-switch in all patients. The maximal plasma concentration (Cmax) and area under the plasma concentration-time curve of IDV decreased significantly (median, 6.3 vs 4.3 μg/mL and 1892 vs 1292 μg·min/mL, P=0.01 and 0.001, respectively) but the minimal plasma concentration remained at a similar level (median, 1.0 vs 0.8 μg/mL, p=0.12). This study found that the reduction in the dosage of IDV in HIV-1 infected patients receiving the standard IDV/RTV regimen guided by therapeutic drug monitoring decreased the Cmax, dose-related toxicity and medical cost without compromising viral control. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-14744295298&partnerID=40&md5=b12bb6c5731ab116348ad8aaef2e2c0f https://scholars.lib.ntu.edu.tw/handle/123456789/515811 |
ISSN: | 1684-1182 | SDG/關鍵字: | antiretrovirus agent; CD4 antigen; indinavir; proteinase inhibitor; virus RNA; adult; article; clinical article; dose response; dose time effect relation; drug blood level; drug dose reduction; drug monitoring; hair loss; hematuria; high performance liquid chromatography; highly active antiretroviral therapy; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; leukocyte count; low back pain; nausea; nephrolithiasis; skin disease; Taiwan; treatment outcome; virus infection; virus load; Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; HIV-1; Humans; Indinavir; Pilot Projects |
顯示於: | 醫學系 |
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