https://scholars.lib.ntu.edu.tw/handle/123456789/517923
Title: | Prevalence and clinical correlates of flunitrazepam-related complex sleep behaviors | Authors: | Tsai J.-K. Yen C.-N. Chen C.-S. TZUNG-JENG HWANG Chen S.-T. Chen T.-T. Ko C.-H. Su P.-W. Chang Y.-P. Lin J.-J. Yen C.-F. |
Keywords: | alcohol use; complex sleep behaviors; dosage; flunitrazepam; prevalence | Issue Date: | 2017 | Journal Volume: | 71 | Journal Issue: | 3 | Start page/Pages: | 198-203 | Source: | Psychiatry and Clinical Neurosciences | Abstract: | Aim: Complex sleep behaviors (CSB) are often associated with the use of hypnotic drugs. This study investigated the prevalence and correlates of CSB among psychiatric patients who were given flunitrazepam. Methods: From June 2011 to May 2012, a total of 268 psychiatric outpatients who had received flunitrazepam for at least 3 months were enrolled. Data on occurrence of CSB, demographic characteristics, flunitrazepam dosage and duration of use, psychiatric diagnoses, physical illnesses, and alcohol use were collected. Logistic regression analysis was used to examine the clinical correlates of CSB. Results: Sixty-six participants (24.6%) reported experiencing CSB. Logistic regression analysis showed that a high dosage (>2 mg/day) of flunitrazepam (odds ratio [OR] = 1.941, 95% confidence interval [CI] = 1.090–3.455, P = 0.024) and alcohol use (OR = 1.948, 95%CI = 1.023–3.709, P = 0.042) were significantly associated with the occurrence of CSB. Sex, age, duration of flunitrazepam use, psychiatric diagnoses, and physical illnesses were not significantly associated with the occurrence of CSB. Conclusion: CSB among flunitrazepam users should be monitored routinely, especially among those receiving a high dosage who also consume alcohol. ? 2016 The Authors. Psychiatry and Clinical Neurosciences ? 2016 Japanese Society of Psychiatry and Neurology |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85007381220&doi=10.1111%2fpcn.12472&partnerID=40&md5=3a571707ab7a35fb217c3ae71e27f169 https://scholars.lib.ntu.edu.tw/handle/123456789/517923 |
ISSN: | 1323-1316 | DOI: | 10.1111/pcn.12472 | SDG/Keyword: | flunitrazepam; flunitrazepam; hypnotic sedative agent; adult; alcohol consumption; Article; behavior disorder; clinical effectiveness; complex sleep behavior; complex sleep behavior; controlled study; demography; disease association; dose response; drug efficacy; drug megadose; drug safety; drug tolerability; drug use; female; human; major clinical study; male; mental disease; treatment duration; drug effects; middle aged; prevalence; sleep; Sleep Initiation and Maintenance Disorders; Adult; Female; Flunitrazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Prevalence; Sleep; Sleep Initiation and Maintenance Disorders |
Appears in Collections: | 醫療器材與醫學影像研究所 |
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