https://scholars.lib.ntu.edu.tw/handle/123456789/518244
標題: | Photo-induced antitumor effect of 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide | 作者: | Chou Y.-S Chang C.-C Chang T.-C TSUNG-LIN YANG Tai-Horng Young PEI-JEN LOU |
公開日期: | 2013 | 卷: | 2013 | 來源出版物: | BioMed Research International | 摘要: | We have applied a fluorescent molecule 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC) for tumor targeting and treatment. In this study, we investigated the photo-induced antitumor effect of BMVC. In vitro cell line studies showed that BMVC significantly killed TC-1 tumor cells at light dose greater than 40 J/cm2. The fluorescence of BMVC in the tumor peaked at 3 hours and then gradually decreased to reach the control level after 24 hours. In vivo tumor treatment studies showed BMVC plus light irradiation (iPDT) significantly inhibited the tumor growth. At day 24 after tumor implantation, tumor volume was measured to be 225 ± 79 mm3, 2542 ± 181 mm3, 1533 ± 766 mm3, and 1317 ± 108 mm3 in the iPDT, control, light-only, and BMVC-only groups, respectively. Immunohistochemistry studies showed the microvascular density was significantly lower in the iPDT group. Taken together, our results demonstrated that BMVC may be a potent tumor-specific photosensitizer (PS) for PDT. ? 2013 Ya-Shuan Chou et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874628274&doi=10.1155%2f2013%2f930281&partnerID=40&md5=2eaa736a402c2ee9e6f4ebef10dde85c https://scholars.lib.ntu.edu.tw/handle/123456789/518244 |
ISSN: | 2314-6133 | DOI: | 10.1155/2013/930281 | SDG/關鍵字: | 3,6 bis(1 methyl 4 vinylpyridinium)carbazole diiodide; antineoplastic agent; unclassified drug; 3,6 bis(1 methyl 4 vinylpyridium)carbazole diiodide; 3,6-bis(1-methyl-4-vinylpyridium)carbazole diiodide; antineoplastic agent; carbazole derivative; photosensitizing agent; pyridinium derivative; animal cell; animal experiment; animal model; antineoplastic activity; article; cancer inhibition; controlled study; density; fluorescence; immunohistochemistry; in vitro study; in vivo study; light; lung tumor; male; mouse; nonhuman; photodynamic therapy; single drug dose; tumor cell; tumor volume; animal; C57BL mouse; drug effect; human; microcirculation; neoplasm; tumor cell line; Animals; Antineoplastic Agents; Carbazoles; Cell Line, Tumor; Fluorescence; Humans; Light; Male; Mice; Mice, Inbred C57BL; Microcirculation; Neoplasms; Photosensitizing Agents; Pyridinium Compounds |
顯示於: | 醫學系 |
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