https://scholars.lib.ntu.edu.tw/handle/123456789/518269
標題: | Feasibility of preservation of the submandibular gland during neck dissection in patients with early-stage oral cancer | 作者: | TSENG-CHENG CHEN PEI-JEN LOU JENG-YUH KO TSUNG-LIN YANG Lo W.-C Hu Y.-L CHENG-PING WANG |
公開日期: | 2011 | 卷: | 18 | 期: | 2 | 起(迄)頁: | 497-504 | 來源出版物: | Annals of Surgical Oncology | 摘要: | Background: The impact of submandibular gland (SMG) preservation during neck dissection on the survival of patients with early-stage oral squamous-cell carcinoma (OSCC) remains undocumented. Methods: The medical records of all patients with early-stage OSCC (stage I and II) who underwent wide excision of the primary tumor and simultaneous neck dissection between 1999 and 2006 at our facility were retrospectively reviewed. Results: We analyzed 408 patients, including 33 patients with and 375 patients without SMG preservation. The 5-year disease-free and overall survival rates were 78.8% and 90.9% for the patients with SMG preservation and 75.4% and 90.4% for the patients without SMG preservation, and these differences were not statistically significant (P = 0.79, P = 0.99, respectively). Similar survival rates between patients with and without SMG preservation were observed in those with oral tongue squamous-cell carcinoma (SCC) and with buccal SCC. Patients with T2 OSCC with SMG preservation had significantly lower 5-year disease-free survival rate than those without SMG preservation (P = 0.02), but overall survival rates were similar between these two groups. Conclusions: Preservation of the SMG during neck dissection may be oncologically safe in patients with T1 OSCC, but the feasibility of SMG preservation seems less clear for T2 OSCC. ? 2010 Society of Surgical Oncology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79951552588&doi=10.1245%2fs10434-010-1294-7&partnerID=40&md5=1912aa3aeeefafb976b5d1832af451af https://scholars.lib.ntu.edu.tw/handle/123456789/518269 |
ISSN: | 1068-9265 | DOI: | 10.1245/s10434-010-1294-7 | SDG/關鍵字: | adult; aged; article; cancer patient; cancer staging; cancer surgery; cancer survival; controlled study; disease free survival; early cancer; feasibility study; female; gingiva tumor; hard palate tumor; human; lip tumor; major clinical study; male; mouth carcinoma; neck dissection; oral squamous cell carcinoma; overall survival; retrospective study; submandibular gland; surgical approach; survival rate; tongue carcinoma; tongue squamous cell carcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Feasibility Studies; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neck Dissection; Neoplasm Staging; Retrospective Studies; Submandibular Gland; Survival Rate; Treatment Outcome; Young Adult |
顯示於: | 醫學系 |
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