Feasibility of preservation of the submandibular gland during neck dissection in patients with early-stage oral cancer
Journal
Annals of Surgical Oncology
Journal Volume
18
Journal Issue
2
Pages
497-504
Date Issued
2011
Author(s)
Abstract
Background: The impact of submandibular gland (SMG) preservation during neck dissection on the survival of patients with early-stage oral squamous-cell carcinoma (OSCC) remains undocumented. Methods: The medical records of all patients with early-stage OSCC (stage I and II) who underwent wide excision of the primary tumor and simultaneous neck dissection between 1999 and 2006 at our facility were retrospectively reviewed. Results: We analyzed 408 patients, including 33 patients with and 375 patients without SMG preservation. The 5-year disease-free and overall survival rates were 78.8% and 90.9% for the patients with SMG preservation and 75.4% and 90.4% for the patients without SMG preservation, and these differences were not statistically significant (P = 0.79, P = 0.99, respectively). Similar survival rates between patients with and without SMG preservation were observed in those with oral tongue squamous-cell carcinoma (SCC) and with buccal SCC. Patients with T2 OSCC with SMG preservation had significantly lower 5-year disease-free survival rate than those without SMG preservation (P = 0.02), but overall survival rates were similar between these two groups. Conclusions: Preservation of the SMG during neck dissection may be oncologically safe in patients with T1 OSCC, but the feasibility of SMG preservation seems less clear for T2 OSCC. ? 2010 Society of Surgical Oncology.
SDGs
Other Subjects
adult; aged; article; cancer patient; cancer staging; cancer surgery; cancer survival; controlled study; disease free survival; early cancer; feasibility study; female; gingiva tumor; hard palate tumor; human; lip tumor; major clinical study; male; mouth carcinoma; neck dissection; oral squamous cell carcinoma; overall survival; retrospective study; submandibular gland; surgical approach; survival rate; tongue carcinoma; tongue squamous cell carcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Feasibility Studies; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neck Dissection; Neoplasm Staging; Retrospective Studies; Submandibular Gland; Survival Rate; Treatment Outcome; Young Adult
Type
journal article