https://scholars.lib.ntu.edu.tw/handle/123456789/519178
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HORNG-HUEI LIOU | en_US |
dc.contributor.author | Wu C.-Y. | en_US |
dc.contributor.author | Chiu Y.-H. | en_US |
dc.contributor.author | Yen A.M.-F. | en_US |
dc.contributor.author | Chen R.-C. | en_US |
dc.contributor.author | TA-FU CHEN | en_US |
dc.contributor.author | Chen C.-C. | en_US |
dc.contributor.author | Hwang Y.-C. | en_US |
dc.contributor.author | Wen Y.-R. | en_US |
dc.contributor.author | Chen, Tony Hsiu Hsi | en_US |
dc.date.accessioned | 2020-11-03T09:53:32Z | - |
dc.date.available | 2020-11-03T09:53:32Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-40449107427&doi=10.1111%2fj.1365-2753.2007.00832.x&partnerID=40&md5=43cca637ce9f9485a32e57a34cbe7539 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/519178 | - |
dc.description.abstract | Objectives: The natural course of Parkinson's disease (PD), as measured on the Hoehn-Yahr (H-Y) scale, and the impact that early detection would have on prognosis for those with the disease, has barely been addressed since the introduction of L-dopa. This study aimed to elucidate the natural history of PD and effectiveness of early detection in reducing advanced disability and mortality. Method: A total of 21 362 participants aged 40 years or older were invited to two community-based programmes for the early detection of PD. The step-by-step annual progression rates from H-Y stage I to stage IV or V, and cumulative survival rates, by the H-Y scale, were estimated and applied to simulated data to assess the impact of different screening intervals upon stage at diagnosis and subsequent survival. Results: The average duration in stages I, II and III was estimated as 2.83, 6.62 and 1.41 years, respectively. The average delay time before deteriorating into H-Y stage III was 9.45 year. Application of these parameters to simulated model predicted a 36% (95% CI: 28-39%), 26% (95% CI: 20-32%) and 19% (95% CI: 13-24%) reduction in death for annual, 5-yearly and 10-yearly screening programmes, respectively. Conclusion: The present study recommended a 5-yearly screening programme, with 74% of PD cases prevented from progressing to H-Y stage III or worse within 10 years of diagnosis, and leading to a corresponding 26% reduction in mortality. ? 2008 The Authors. | - |
dc.relation.ispartof | Journal of Evaluation in Clinical Practice | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; article; community program; disability; disease duration; early diagnosis; human; major clinical study; mortality; Parkinson disease; priority journal; screening; survival rate; Taiwan; Adult; Community Health Services; Computer Simulation; Early Diagnosis; Female; Humans; Male; Middle Aged; Parkinson Disease; Program Evaluation; Statistics as Topic; Taiwan | - |
dc.title | Natural history and effectiveness of early detection of Parkinson's disease: Results from two community-based programmes in Taiwan (KCIS no. 11) | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1365-2753.2007.00832.x | - |
dc.identifier.pmid | 18284524 | - |
dc.identifier.scopus | 2-s2.0-40449107427 | - |
dc.relation.pages | 198-202 | - |
dc.relation.journalvolume | 14 | - |
dc.relation.journalissue | 2 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Pharmacology | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.dept | Institute of Health Data Analytics and Statistics | - |
crisitem.author.dept | Public Health | - |
crisitem.author.orcid | 0000-0001-6537-5346 | - |
crisitem.author.orcid | 0000-0003-1988-6924 | - |
crisitem.author.orcid | 0000-0002-5799-6705 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
顯示於: | 醫學系 |
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