https://scholars.lib.ntu.edu.tw/handle/123456789/519178
標題: | Natural history and effectiveness of early detection of Parkinson's disease: Results from two community-based programmes in Taiwan (KCIS no. 11) | 作者: | HORNG-HUEI LIOU Wu C.-Y. Chiu Y.-H. Yen A.M.-F. Chen R.-C. TA-FU CHEN Chen C.-C. Hwang Y.-C. Wen Y.-R. Chen, Tony Hsiu Hsi |
公開日期: | 2008 | 卷: | 14 | 期: | 2 | 起(迄)頁: | 198-202 | 來源出版物: | Journal of Evaluation in Clinical Practice | 摘要: | Objectives: The natural course of Parkinson's disease (PD), as measured on the Hoehn-Yahr (H-Y) scale, and the impact that early detection would have on prognosis for those with the disease, has barely been addressed since the introduction of L-dopa. This study aimed to elucidate the natural history of PD and effectiveness of early detection in reducing advanced disability and mortality. Method: A total of 21 362 participants aged 40 years or older were invited to two community-based programmes for the early detection of PD. The step-by-step annual progression rates from H-Y stage I to stage IV or V, and cumulative survival rates, by the H-Y scale, were estimated and applied to simulated data to assess the impact of different screening intervals upon stage at diagnosis and subsequent survival. Results: The average duration in stages I, II and III was estimated as 2.83, 6.62 and 1.41 years, respectively. The average delay time before deteriorating into H-Y stage III was 9.45 year. Application of these parameters to simulated model predicted a 36% (95% CI: 28-39%), 26% (95% CI: 20-32%) and 19% (95% CI: 13-24%) reduction in death for annual, 5-yearly and 10-yearly screening programmes, respectively. Conclusion: The present study recommended a 5-yearly screening programme, with 74% of PD cases prevented from progressing to H-Y stage III or worse within 10 years of diagnosis, and leading to a corresponding 26% reduction in mortality. ? 2008 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-40449107427&doi=10.1111%2fj.1365-2753.2007.00832.x&partnerID=40&md5=43cca637ce9f9485a32e57a34cbe7539 https://scholars.lib.ntu.edu.tw/handle/123456789/519178 |
DOI: | 10.1111/j.1365-2753.2007.00832.x | SDG/關鍵字: | adult; article; community program; disability; disease duration; early diagnosis; human; major clinical study; mortality; Parkinson disease; priority journal; screening; survival rate; Taiwan; Adult; Community Health Services; Computer Simulation; Early Diagnosis; Female; Humans; Male; Middle Aged; Parkinson Disease; Program Evaluation; Statistics as Topic; Taiwan |
顯示於: | 醫學系 |
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