https://scholars.lib.ntu.edu.tw/handle/123456789/524988
標題: | The influence of breastfeeding in breast-fed infants with atopic dermatitis | 作者: | Lin H.-P. BOR-LUEN CHIANG HSIN-HUI YU JYH-HONG LEE YU-TSAN LIN YAO-HSU YANG LI-CHIEH WANG |
公開日期: | 2019 | 出版社: | Elsevier Ltd | 卷: | 52 | 期: | 1 | 起(迄)頁: | 132-140 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background: The aim of this study was to evaluate whether breastfeeding should be discontinued for exclusively breast-fed infants with atopic dermatitis (AD). Methods: Eighty-seven exclusively breast-fed infants with AD were enrolled in a prospective observational study. The infants were divided into 3 groups: breastfeeding only (BM group), partial breastfeeding and partial partially hydrolyzed whey formula (pHF-W) (Partial group) and pHF-W only (DC group). The extent and severity of AD were evaluated with the Patient-Oriented SCORing Atopic Dermatitis (PO-SCORAD) index at enrollment and 3 and 6 months later. Results: There were no significant differences in parental atopy history, PO-SCORAD scores, and medication scores at baseline. At month 3 and 6, the PO-SCORAD scores were significantly decreased in all groups. PO-SCORAD scores at month 3 and 6 and at the last time point when topical corticosteroids were given were significantly different among the groups. Stepwise multiple linear regression analysis showed that baseline PO-SCORAD scores and stopping breastfeeding were significantly associated with month 3 PO-SCORAD scores (p < 0.001), after adjusting for sex, age, baseline medication scores, partial breastfeeding and parental atopy history. In addition to baseline PO-SCORAD scores and stopping breastfeeding, partial breastfeeding was significantly associated with month 6 PO-SCORAD scores. Long-term follow-up showed that only stopping breastfeeding was significantly associated with the last time point when topical corticosteroids were given (p = 0.014). Conclusion: For exclusively breast-fed infants with AD, discontinuing breastfeeding and shifting to pHF-W might help to improve symptoms and shorten the duration of AD regardless of sex, age and parental atopy history. ? 2017 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85023622521&doi=10.1016%2fj.jmii.2017.06.004&partnerID=40&md5=2b6a6f98abfc28354c907ae2d6cb04de https://scholars.lib.ntu.edu.tw/handle/123456789/524988 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2017.06.004 | SDG/關鍵字: | antibiotic agent; antihistaminic agent; corticosteroid; emollient agent; fluticasone propionate; prednisolone; corticosteroid; age; Article; artificial milk; atopic dermatitis; atopy; breast feeding; breast feeding education; child; child parent relation; disease severity; family history; female; follow up; human; infant; major clinical study; male; milk; observational study; patient oriented scoring atopic dermatitis score; preschool child; prospective study; questionnaire; self evaluation; atopic dermatitis; pathology; risk factor; severity of illness index; Adrenal Cortex Hormones; Breast Feeding; Dermatitis, Atopic; Female; Humans; Infant; Male; Prospective Studies; Risk Factors; Self-Assessment; Severity of Illness Index; Surveys and Questionnaires |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。