https://scholars.lib.ntu.edu.tw/handle/123456789/524999
標題: | Clinical characteristics of children with positive anti-SSA/SSB antibodies | 作者: | Chen P.-H. YAO-HSU YANG YU-TSAN LIN JYH-HONG LEE LI-CHIEH WANG HSIN-HUI YU BOR-LUEN CHIANG |
公開日期: | 2014 | 出版社: | Springer Verlag | 卷: | 34 | 期: | 8 | 起(迄)頁: | 1123-1127 | 來源出版物: | Rheumatology International | 摘要: | This study aimed to characterize the manifestations of clinical symptoms and signs, primary rheumatic diseases, and other autoantibodies in pediatric patients with positive anti-SSA and/or anti-SSB antibodies. Subjects under age 18 with positive anti-SSA and/or anti-SSB antibodies were screened and enrolled in a tertiary hospital in Taiwan. Data were collected via medical records, including age, gender, onset of the primary rheumatic disease, clinical symptoms and signs, and the medication used. Schirmer test for Sj?gren's syndrome (SS) screening was performed in all enrolled patients. Among twenty enrolled subjects, seventeen of them had systemic lupus erythematosus; four of them were diagnosed as SS with positive Schirmer test. In addition to antinuclear antibodies and anti-DNA antibodies, other common autoantibodies were anti-RNP antibodies (50 %) and anti-Sm antibodies (30 %). The most common symptoms were arthritis (60 %) followed by malar rash (40 %). In conclusion, we observed that a low proportion of childhood SS (4/20) exists in our patients with positive SSA and/or anti-SSB antibodies. It is suggested that clinicians should focus more on the clinical symptoms in these patients, rather than undertaking invasive diagnostic interventions to rule out Sj?gren's syndrome. ? 2013 Springer-Verlag. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904807377&doi=10.1007%2fs00296-013-2870-5&partnerID=40&md5=6f9a9ba43ca9599121dc362e81c20c03 https://scholars.lib.ntu.edu.tw/handle/123456789/524999 |
ISSN: | 0172-8172 | DOI: | 10.1007/s00296-013-2870-5 | SDG/關鍵字: | antinuclear antibody; azathioprine; cyclosporin; DNA antibody; hydroxychloroquine; La antibody; methotrexate; mycophenolic acid 2 morpholinoethyl ester; nonsteroid antiinflammatory agent; ribonucleoprotein antibody; Ro antibody; Sm antibody; steroid; antinuclear antibody; biological marker; SS-A antibodies; SS-B antibodies; adolescent; adult; alopecia; arthritis; article; autoimmune lymphoproliferative syndrome; child; clinical article; drug industry; enthesitis; female; gastrointestinal symptom; hematologic disease; human; immunosuppressive treatment; inflammation; kidney disease; male; marginal zone lymphoma; medical record review; mouth ulcer; mucocutaneous lymph node syndrome; neurologic disease; photosensitivity; precocious puberty; preschool child; priority journal; purpura; rash; Schirmer test; school child; screening test; Sjoegren syndrome; systemic lupus erythematosus; arthritis; blood; differential diagnosis; Exanthema; immunology; Lupus Erythematosus, Systemic; onset age; predictive value; Sjogren's Syndrome; Taiwan; tertiary care center; Adolescent; Age of Onset; Antibodies, Antinuclear; Arthritis; Biological Markers; Child; Child, Preschool; Diagnosis, Differential; Exanthema; Female; Humans; Lupus Erythematosus, Systemic; Male; Predictive Value of Tests; Sjogren's Syndrome; Taiwan; Tertiary Care Centers |
顯示於: | 醫學系 |
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