https://scholars.lib.ntu.edu.tw/handle/123456789/525024
標題: | The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells | 作者: | LI-CHIEH WANG Lin Y.-L. Liang Y.-C. YAO-HSU YANG JYH-HONG LEE HSIN-HUI YU Wu W.-M. BOR-LUEN CHIANG |
公開日期: | 2009 | 卷: | 10 | 起(迄)頁: | 39 | 來源出版物: | BMC Immunology | 摘要: | Background: Propolis, an ancient herbal medicine, has been reported the beneficial effect both in asthma patients and murine model of asthma, but the mechanism was not clearly understood. In this study, the effect of caffeic acid phenethyl ester (CAPE), the most extensively studied components in propolis, on the functions of human monocyte-derived dendritic cells (MoDCs) was investigated. Results: CAPE significantly inhibited IL-12 p40, IL-12 p70, IL-10 protein expression in mature healthy human MoDCs stimulated by lipopolysaccharides (LPS) and IL-12 p40, IL-10, IP-10 stimulated by crude mite extract. CAPE significantly inhibited IL-10 and IP-10 but not IL-12 expression in allergic patients' MoDCs stimulated by crude mite extract. In contrast, the upregulation of costimulatory molecules in mature MoDCs was not suppressed by CAPE. Further, the antigen presenting ability of DCs was not inhibited by CAPE. CAPE inhibited IκBα phosphorylation and NF-κB activation but not mitogen-activated protein kinase (MAPK) family phosphorylation in human MoDCs. Conclusion: These results indicated that CAPE inhibited cytokine and chemokine production by MoDCs which might be related to the NF-κB signaling pathway. This study provided a new insight into the mechanism of CAPE in immune response and the rationale for propolis in the treatment of asthma and other allergic disorders. ? 2009 Wang et al; licensee BioMed Central Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-68949211250&doi=10.1186%2f1471-2172-10-39&partnerID=40&md5=29bb6ba44ee590e1b3f1cef5879adcc8 https://scholars.lib.ntu.edu.tw/handle/123456789/525024 |
ISSN: | 1471-2172 | DOI: | 10.1186/1471-2172-10-39 | SDG/關鍵字: | B7 antigen; caffeic acid phenethyl ester; CD83 antigen; CD86 antigen; gamma interferon inducible protein 10; HLA DR antigen; I kappa B alpha; immunoglobulin enhancer binding protein; interleukin 10; interleukin 12p40; interleukin 12p70; lipopolysaccharide; mitogen activated protein kinase; propolis; allergen; caffeic acid derivative; caffeic acid phenethyl ester; CXCL10 protein, human; drug derivative; gamma interferon inducible protein 10; I kappa B kinase; interleukin 10; interleukin 12; interleukin 12p40; lipopolysaccharide; mitogen activated protein kinase kinase; phenethyl alcohol; antigen presentation; article; cell function; controlled study; cytokine production; dendritic cell; gene activation; human; human cell; monocyte derived dendritic cell; phagocytosis; protein expression; protein phosphorylation; signal transduction; T lymphocyte activation; upregulation; animal; drug antagonism; drug effect; hypersensitivity; immunology; metabolism; phosphorylation; Pyroglyphidae; T lymphocyte; Allergens; Animals; Caffeic Acids; Chemokine CXCL10; Dendritic Cells; Humans; Hypersensitivity; I-kappa B Kinase; Interleukin-10; Interleukin-12; Interleukin-12 Subunit p40; Lipopolysaccharides; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Phenylethyl Alcohol; Phosphorylation; Propolis; Pyroglyphidae; Signal Transduction; T-Lymphocytes |
顯示於: | 醫學系 |
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