|Title:||The 1998 enterovirus 71 outbreak in Taiwan: Pathogenesis and management||Authors:||Lin T.-Y.
|Issue Date:||2002||Journal Volume:||34||Start page/Pages:||S52-S57||Source:||Clinical Infectious Diseases||Abstract:||
The most recently discovered enterovirus, enterovirus 71 (EV71), is neurotropic and may cause severe disease and sudden death in children. In 1998, a large outbreak of enterovirus infection occurred in Taiwan that resulted in 405 severe cases in children and 78 deaths. Of the 78 children who died, 71 (91%) were <5 years old. EV71 was the primary agent in fatal cases of infection. Most of these patients died within 1-2 days of admission to the hospital. We hypothesize that EV71 directly attacks the central nervous system and causes neurogenic pulmonary edema and cardiac decompensation through the mechanism of sympathetic hyperactivity and inflammatory responses. Early recognition of risk factors and intensive care are crucial to successful treatment of this fulminant infection. After poliovirus is eradicated, EV71 will become the most important enterovirus that affects children, and development of a vaccine may be the only effective measure against it.
|ISSN:||1058-4838||DOI:||10.1086/338819||metadata.dc.subject.other:||antivirus agent; age; central nervous system infection; disease course; disease severity; early diagnosis; Enterovirus 71; epidemic; fatality; heart failure; hospital admission; human; hypothesis; inflammation; intensive care; lung edema; neurotropism; nucleotide sequence; pathogenesis; Poliomyelitis virus; priority journal; review; risk factor; sudden death; sympathetic tone; Taiwan; vaccine production; virus infection; virus typing; Convalescence; Disease Management; Disease Outbreaks; Encephalomyelitis; Enterovirus; Enterovirus Infections; Herpangina; Humans; Hypertension; Taiwan
|Appears in Collections:||醫學系|
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