https://scholars.lib.ntu.edu.tw/handle/123456789/525696
標題: | The 1998 enterovirus 71 outbreak in Taiwan: Pathogenesis and management | 作者: | Lin T.-Y. LUAN-YIN CHANG Hsia S.-H. Huang Y.-C. Chiu C.-H. Hsueh C. Shih S.-R. Liu C.-C. MEI-HWAN WU |
公開日期: | 2002 | 卷: | 34 | 起(迄)頁: | S52-S57 | 來源出版物: | Clinical Infectious Diseases | 摘要: | The most recently discovered enterovirus, enterovirus 71 (EV71), is neurotropic and may cause severe disease and sudden death in children. In 1998, a large outbreak of enterovirus infection occurred in Taiwan that resulted in 405 severe cases in children and 78 deaths. Of the 78 children who died, 71 (91%) were <5 years old. EV71 was the primary agent in fatal cases of infection. Most of these patients died within 1-2 days of admission to the hospital. We hypothesize that EV71 directly attacks the central nervous system and causes neurogenic pulmonary edema and cardiac decompensation through the mechanism of sympathetic hyperactivity and inflammatory responses. Early recognition of risk factors and intensive care are crucial to successful treatment of this fulminant infection. After poliovirus is eradicated, EV71 will become the most important enterovirus that affects children, and development of a vaccine may be the only effective measure against it. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036569962&doi=10.1086%2f338819&partnerID=40&md5=e824764b7970ba007df74f76a555fcbe https://scholars.lib.ntu.edu.tw/handle/123456789/525696 |
ISSN: | 1058-4838 | DOI: | 10.1086/338819 | SDG/關鍵字: | antivirus agent; age; central nervous system infection; disease course; disease severity; early diagnosis; Enterovirus 71; epidemic; fatality; heart failure; hospital admission; human; hypothesis; inflammation; intensive care; lung edema; neurotropism; nucleotide sequence; pathogenesis; Poliomyelitis virus; priority journal; review; risk factor; sudden death; sympathetic tone; Taiwan; vaccine production; virus infection; virus typing; Convalescence; Disease Management; Disease Outbreaks; Encephalomyelitis; Enterovirus; Enterovirus Infections; Herpangina; Humans; Hypertension; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。